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Evaluation of New Naphthalimides as Potential Anticancer Agents against Breast Cancer MCF-7, Pancreatic Cancer BxPC-3 and Colon Cancer HCT- 15 Cell Lines | Abstract
ISSN: 2161-0401

Organic Chemistry: Current Research
Open Access

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Research Article

Evaluation of New Naphthalimides as Potential Anticancer Agents against Breast Cancer MCF-7, Pancreatic Cancer BxPC-3 and Colon Cancer HCT- 15 Cell Lines

Noro J1*, Maciel J2, Duarte D1, Olival ACD3, Baptista C2, Silva ACD2,4, Alves MJ1 and Kong Thoo Lin P3
1Department of Chemistry, Campus de Gualtar, University of Minho, Braga, Portugal
2Parasite Disease Group, Institute for Molecular and Cell Biology (IBMC), University of Porto, Porto, Portugal
3School of Pharmacy and Life Sciences, Robert Gordon University, Riverside East, Garthdee Road, Aberdeen AB10 1GJ, Scotland
4Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
Corresponding Author : Jennifer Noro
Department of Chemistry, Campus de Gualtar
University of Minho, Braga, Portugal
Tel: +351 916295655
E-mail: [email protected]
Received: June 25, 2015; Accepted: July 13, 2015; Published: July 20, 2015
Citation: Noro J, Maciel J, Duarte D, Olival ACD, Baptista C, et al. (2015) Evaluation of New Naphthalimides as Potential Anticancer Agents against Breast Cancer MCF-7, Pancreatic Cancer BxPC-3 and Colon Cancer HCT-15 Cell Lines. Organic Chem Curr Res 4:144. doi:10.4172/2161-0401.1000144
Copyright: © 2015 Noro J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally structures with shorter alkyl chains were more active, with the one exception of the amide containing a p-nitrophenyl group. GI50 values (μM) were determined for the most active compounds. Three compounds exhibited GI50 values below 5 μM, two with MCF-7 cells, and one other with HCT-15. Compounds with different functionalities demonstrated cell line specificity: the MCF-7 cell line was more sensitive to an urea derivative (6f), the growth of HCT- 15 cells were most affected by a triazole (9d), while the BxPC-3 cell line was inhibited in a higher extend by a guanidine (4a).

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