Evaluation of Renal Denervation by 24-Hour Ambulatory Blood Pressure and Quantified Antihypertensive Medication
Lene Kjær Olsen*, Anne-Lise Kamper DMSc, Jesper Hastrup Svendsen, Lia EviBang, Marie Frimodt-Møller, HenningKelbæk and Bo Feldt-Rasmussen
Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
- *Corresponding Author:
- Lene Kjær Olsen
Department of Nephrology P 2131 Rigshospitalet
Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Tel: 0045 2685 7714
Fax: 0045 3545 2240
E-mail: [email protected]
Received Date: January 09, 2015; Accepted Date: May 30, 2015; Published Date: June 06, 2015
Citation: Olsen LK, Kamper AL, Svendsen JH, EviBang L, Frimodt-Møller M, et al. (2015) Evaluation of Renal Denervation by 24-Hour Ambulatory Blood Pressure and Quantified Antihypertensive Medication. J Hypertens 4:200. doi:10.4172/2167-1095.1000200
Copyright: ©2015 Olsen LK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Previous studies of renal denervation (RDN) have mainly focused on the effect on office blood pressure (BP) and number of antihypertensive drugs although these are known as sub-optimal endpoints. Aim: The aim of this study was to evaluate the effect of RDN by combining 24-hour ambulatory blood pressure (ABP) measurements and quantified antihypertensive medication at 12 months after RDN. Methods: Fifty-one patients (71% men, mean age 56 years) with resistant hypertension were treated with RDN. Office BP and ABP were measured at baseline and 6 and 12 months after RDN. Concomitantly the administration of antihypertensive drugs was assessed by their total defined daily dose (DDD). Results are presented as mean values ( ± SD)). Results: The change in daytime systolic ABP at 6 and 12 months was -8.6 (22.5) (P=0.01) and -4.2 (22.3) mmHg (P=NS). Quantified antihypertensive medication was assessed, and at 12 months after RDN there was no change in antihypertensive medication in 33% of patients using the DDD method versus 53% of patients using counts of number of antihypertensive drugs (NS). At 12 months after RDN a ≥5 mmHg reduction in MAP (24-hour ABP) was found in 36% of the patients in addition to an unchanged or reduced DDD, whereas this was seen in 42% of patients when number of antihypertensive drugs were used (NS). Conclusions: There was no effect of RDN on ABP after 12 months. We have presented a method that embraces both ABP and quantitative assessment of antihypertensive medication to evaluate RDN by combined ΔDDD/24-hour ΔMAP.