alexa Evaluation of Renal Denervation by 24-Hour Ambulatory B
ISSN: 2167-1095

Journal of Hypertension: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Evaluation of Renal Denervation by 24-Hour Ambulatory Blood Pressure and Quantified Antihypertensive Medication

Lene Kjær Olsen*, Anne-Lise Kamper DMSc, Jesper Hastrup Svendsen, Lia EviBang, Marie Frimodt-Møller, HenningKelbæk and Bo Feldt-Rasmussen

Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

*Corresponding Author:
Lene Kjær Olsen
Department of Nephrology P 2131 Rigshospitalet
Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Tel: 0045 2685 7714
Fax: 0045 3545 2240
E-mail: [email protected]

Received Date: January 09, 2015; Accepted Date: May 30, 2015; Published Date: June 06, 2015

Citation: Olsen LK, Kamper AL, Svendsen JH, EviBang L, Frimodt-Møller M, et al. (2015) Evaluation of Renal Denervation by 24-Hour Ambulatory Blood Pressure and Quantified Antihypertensive Medication. J Hypertens 4:200. doi:10.4172/2167-1095.1000200

Copyright: ©2015 Olsen LK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Previous studies of renal denervation (RDN) have mainly focused on the effect on office blood pressure (BP) and number of antihypertensive drugs although these are known as sub-optimal endpoints. Aim: The aim of this study was to evaluate the effect of RDN by combining 24-hour ambulatory blood pressure (ABP) measurements and quantified antihypertensive medication at 12 months after RDN. Methods: Fifty-one patients (71% men, mean age 56 years) with resistant hypertension were treated with RDN. Office BP and ABP were measured at baseline and 6 and 12 months after RDN. Concomitantly the administration of antihypertensive drugs was assessed by their total defined daily dose (DDD). Results are presented as mean values ( ± SD)). Results: The change in daytime systolic ABP at 6 and 12 months was -8.6 (22.5) (P=0.01) and -4.2 (22.3) mmHg (P=NS). Quantified antihypertensive medication was assessed, and at 12 months after RDN there was no change in antihypertensive medication in 33% of patients using the DDD method versus 53% of patients using counts of number of antihypertensive drugs (NS). At 12 months after RDN a ≥5 mmHg reduction in MAP (24-hour ABP) was found in 36% of the patients in addition to an unchanged or reduced DDD, whereas this was seen in 42% of patients when number of antihypertensive drugs were used (NS). Conclusions: There was no effect of RDN on ABP after 12 months. We have presented a method that embraces both ABP and quantitative assessment of antihypertensive medication to evaluate RDN by combined ΔDDD/24-hour ΔMAP.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version