Evaluation of Retinal Nerve Fiber Layer Thickness with Spectral Domain Oct in Primary Open Angle Glaucoma and Ocular Hypertension
|Esra Åahli1* and Oya Tekeli2|
|1Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey|
|2Department of Ophthalmology, Faculty of Medicine Ankara University, Turkey|
|Corresponding Author :||Esra Åahli
Department of Ophthalmology, Faculty of
Medicine, Ankara University, Ankara, Turkey
E-mail: [email protected]
|Received: August 04, 2011; Accepted: September 26, 2012; Published: October 03, 2012|
|Citation: Åahli E, Tekeli O (2012) Evaluation of Retinal Nerve Fiber Layer Thickness with Spectral Domain Oct in Primary Open Angle Glaucoma and Ocular Hypertension. J Clin Exp Ophthalmol 3:247. doi:10.4172/2155-9570.1000247|
|Copyright: © 2012 Åahli E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Related article at
Pubmed Scholar Google
Purpose: To compare Primary Open Angle Glaucoma (POAG), Ocular Hypertension (OHT) and control groups by using Visual Field (VF) and Spectral Domain Optical Coherence Tomography (SD-OCT) and to investigate correlations between VF global indices and Retinal Nerve Fiber Layer (RNFL) thickness measurements.
Methods: Forty patients with POAG, 55 patients with OHT, and 40 normal subjects were included in the study. All subjects were evaluated by standard automated perimetry and Cirrus HD-OCT.
Results: RNFL global average thickness, average thicknesses in four quadrants and at 1 o’clock, 4 o’clock, 5 o’clock, 6 o’clock, 7 o’clock, 10 o’clock, 11 o’clock and 12 o’clock areas in POAG patients were significantly decreased compared with the OHT and the control groups. RNFL thicknesses at 2 o’clock, 8 o’clock and 9 o’clock areas in the POAG group were significantly lower than control subjects. There were statistically significant and a negative correlation between PSD and RNFL global average thickness, RNFL thicknesses in temporal quadrant and at 1 o’clock and 2 o’clock areas in the POAG group. According to the areas under the ROC curve, the parameter which has the best diagnostic ability was found as RNFL thickness in the superior quadrant. The sensitivity and specificity of Cirrus HD-OCT for RNFL thickness in superior quadrant were found 77% and 87%.
Conclusion: The correlations between MD, PSD and RNFL thickness parameters could represent the consistency of functional and structural tests. RNFL measurement with SD-OCT could provide important information for detection of early stages of glaucoma.