alexa Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery | OMICS International| Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Mol Biomark Diagn 2017, Vol 8(6): 6
  • DOI: 10.4172/2155-9929.1000359

Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Cristiana Iacuzzo1, Marina Troian1, Laura Bonadio1, Deborah Bonazza3, Chiara Dobrinja1*, Gabriele Bellio1, Serena Scomersi1,2, Fabiola Giudici2, Fabrizio Zanconati2,3 and Marina Bortul1,2
1Department of General Surgery, University Hospital of Trieste, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy
2Breast Unit, Azienda Sanitaria Universitaria Integrata di Trieste, Italy
3Department of Histopathology, University Hospital of Trieste, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy
*Corresponding Author : Chiara Dobrinja, Department of General Surgery, University Hospital of Trieste, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy, Tel: +39 0403994152, Email: [email protected]

Received Date: May 24, 2017 / Accepted Date: Jul 16, 2017 / Published Date: Jul 20, 2017

Abstract

Background: One of the strongest prognostic factor for breast cancer is the regional lymph node status, which can be evaluated intraoperatively by sentinel lymph node biopsy. Many methods (e.g. frozen section, touch imprint cytology (TIC) and one-step nucleic-acid amplification) are available to detect metastatic cells in axillary lymph nodes. The aim of this study is to evaluate the feasibility of using TIC to detect metastatic cells in sentinel lymph nodes.

Methods: This is a retrospective single center cohort analysis conducted on prospectively recorded data. The study included all patients admitted to the Department of General Surgery of Trieste University Hospital for invasive clinically node-negative breast cancer who underwent sentinel lymph node assessment by means of TIC.

Results: Between January 2015 and December 2016, 343 patients (338 females and 5 males) underwent breast surgery and sentinel lymph node TIC. Patient’s median age was 66 (33-92) years.

The sensitivity of TIC was 54% (95% C.I. 39% to 69%), whereas its specificity and accuracy were 99% (95% C.I. 98% to 100%) and 90%, respectively. The median time required to obtain the result was 20 (15-45) min. The overall cost per each TIC analysis was about 20.50€.

Conclusion: Touch imprint cytology appears to be a fast, cost-effective and reliable technique to intraoperatively detect breast cancer lymph node metastasis.

Keywords: Breast cancer; Touch imprint cytology; Lymph node; Metastases; Axillary dissection

Citation: Iacuzzo C, Troian M, Bonadio L, Bonazza D, Dobrinja C, et al. (2017) Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery. J Mol Biomark Diagn 8: 359. Doi: 10.4172/2155-9929.1000359

Copyright: ©2017 Iacuzzo C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences

15th Global Biomarkers and Clinical Research Summit

Vienna, Austria

2nd International Conference on Biomarkers and Cancer Targets

Capetown, South Africa
Article Usage
  • Total views: 2073
  • [From(publication date): 0-2017 - Jan 26, 2020]
  • Breakdown by view type
  • HTML page views: 1948
  • PDF downloads: 125
Top