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Evaluation of Serum Amyloid A and Haptoglobin in Dairy Cows Naturally Infected with Brucellosis | OMICS International | Abstract
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
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Research Article

Evaluation of Serum Amyloid A and Haptoglobin in Dairy Cows Naturally Infected with Brucellosis

Hassan Sharifiyazdi1*, Saeed Nazifi1, Kasra Nikseresht1 and Reza Shahriari2

1Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

*Corresponding Author:
Hassan Sharifiyazdi
Department of Clinical Studies
School of Veterinary Medicine
Shiraz University, Shiraz, Iran
Tel: +987112286950
Fax: +987112286940
E-mail: [email protected]

Received date: October 08, 2012; Accepted date: November 17, 2012; Published date: November 22, 2012

Citation: Sharifiyazdi H, Nazifi S, Nikseresht K, Shahriari R (2012)Evaluation of Serum Amyloid A and Haptoglobin in Dairy Cows Naturally Infected with Brucellosis. J Bacteriol Parasitol 3:157. doi:10.4172/2155-9597.1000157

Copyright: © 2012 Sharifiyazdi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Brucellosis is one of the most important zoonotic diseases worldwide, which is responsible for a debilitating disease in humans and a chronic infection in domestic animals. The aim of this study was to determine serum changes of two major acute phase proteins (Serum Amyloid A (SAA) and Haptoglobin (Hp)) levels in dairy cows naturally infected with brucellosis. The study included 25 dairy cows with brucellosis and 25 healthy cows. It was found that mean SAA levels (μg/ml) were significantly (P < 0.05) higher in brucellosis cases (123.75 ± 12.64) as compared to values measured in the control group (32.92 ± 9.12). In addition, SAA levels measured in the positive cases correlated with the increase in
antibody levels, both in 2-mercaptoethanol (2ME) and Wright tests. However, the analyses of the results between the evaluated groups did not show any significant differences in measured serum concentration of Hp (g/l) (P > 0.05). Our results suggested that some acute phase proteins are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested SAA may be used as an indicator for bovine brucellosis.

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