alexa Event Related Brain Potentials (ERP) Could Not Assess the Risk of Cognitive Impairment in Relapse-Remitting Multiple Sclerosis (RRMS) | OMICS International| Abstract
ISSN: 2376-0389

Journal of Multiple Sclerosis
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  • Research Article   
  • J Mult Scler,
  • DOI: 10.4172/2376-0389.1000220

Event Related Brain Potentials (ERP) Could Not Assess the Risk of Cognitive Impairment in Relapse-Remitting Multiple Sclerosis (RRMS)

Svetlana Miletic Drakulic1, Ana Vujic2, Ana Azanjac Arsic1, Snezana Lazarevic1, Jasna Jevdjic3 and Dejan Z. Aleksic1*
1Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, Serbia
2Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, Serbia
3Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Serbia
*Corresponding Author : Dejan Z. Aleksic, Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, Serbia, Tel: 381642287184, Email: [email protected]

Received Date: May 13, 2018 / Accepted Date: Jun 12, 2018 / Published Date: Jun 19, 2018

Abstract

 Objectives: The first objective of our study was to determine differences between groups of patients receiving disease modifying therapy (DMTs) (INFβ-1a and INFβ-1b), patients without DMTs and a control group, in terms of neuropsychological tests and event-related brain potentials (ERP). The second objective was to determine factors that may serve to assess the risk of cognitive impairment in patients with relapsing remitting multiple sclerosis (RRMS). Methods: A total of 81 RRMS patients (mean age 41.09 ± 8.71 years old, 51 women, mean disease duration 133.05 ± 76.56 months) and 32 healthy controls participated in the study. Cognitive functions were evaluated using a standard PASAT-3, the symbol digit modality test (SDMT) and ERP. Results: There were statistically significant differences between the mean values for parietal (Pz) (p ≤ 0.05) and central (Cz) latency (p<0.05) between the four groups of study participants. RRMS increased the risk of cognitive impairment approximately 3.5 fold. Each year of age raised the risk of cognitive impairment by 6.0%. Each unit increase in level of education reduced the risk of cognitive impairment approximately 2.5 fold. Increase in reaction time (RT) Cz by 1 ms elevated the risk of cognitive impairment by 0.5%. Conclusions: There were statistically significant differences between the mean values of Pz and Cz latency between the four groups of study participants. Factors that may be used to assess the risk of developing cognitive impairment in patients with RRMS include age, education level, and RT Cz. However, ERP (latency and amplitude) did not independently assess the risk of cognitive impairment in RRMS patients.

Keywords:  Event related brain potentials; Cognitive impairment; Multiple sclerosis; PASAT; SDMT; INFβ 

Citation: Drakulic SM, Vujic A, Arsic AA, Lazarevic S, Jevdjic J, et al. (2018) Event Related Brain Potentials (ERP) Could Not Assess the Risk of Cognitive Impairment in Relapse-Remitting Multiple Sclerosis (RRMS). J Mult Scler (Foster City) 5: 220. Doi: 10.4172/2376-0389.1000220

Copyright: © 2018 Drakulic SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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