alexa Event-Related Potentials for Cognitive Assessment of Patients with Epilepsy | OMICS International | Abstract
ISSN: 2161-0665

Pediatrics & Therapeutics
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Research Article

Event-Related Potentials for Cognitive Assessment of Patients with Epilepsy

Yoshimi Kaga1,2*, Hideaki Kanemura1, Sayaka Ishii2, Shigeaki Kaga3 and Masao Aihara4

1Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

2National Hospital Organization Kofu National Hospital, Yamanashi, Japan

3Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

4Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

*Corresponding Author:
Yoshimi Kaga
Department of Pediatrics, Faculty of Medicine
University of Yamanashi, 1110 Shimokato
Chuo City, Yamanashi 409-3898, Japan
Tel: +81-55-273-9606
Fax: +81-55-273-6745
E-mail: [email protected]

Received Date: June 04, 2013; Accepted Date: July 27, 2013; Published Date: July 29, 2013

Citation: Kaga Y, Kanemura H, Ishii S, Kaga S, Aihara M (2013) Event-Related Potentials for Cognitive Assessment of Patients with Epilepsy. Pediat Therapeut 3:161. doi: 10.4172/2161-0665.1000161

Copyright: © 2013 Kaga Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Event-related potentials (ERPs) are very useful for evaluating cognitive function in patients with neurological and psychiatric disorders. The method is noninvasive, economical, and offers a certain level of temporal resolution. This review focuses on cognitive functions in epilepsy patients using various ERPs, such as P300, mismatch negativity, NoGo potentials, cognitive negative variation and working memory paradigms. Patients with epilepsy show impaired cognitive functions in the form of selective attention, pre-attentive cognitive function, working memory and frontal inhibitory functions. These impairments come from either the epileptogenic focus or the effects of therapy. Antiepileptic drugs (AEDs) influence cognitive functions. These influences may be dose-dependent and can improve after discontinuation. By assessing various ERPs, the clinician can evaluate cognitive functions, differential diagnoses and the effects of AEDs in patients with epilepsy. Furthermore, these evaluations can lead to improved quality of life for patients.

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