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ISSN: 2161-0495

Journal of Clinical Toxicology
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Review Article

Evidence Based Phytopharmacological Potential of Herbal Extracts in Post-Ingestion Management of Mycotoxins in Animal Models

Juma KK1*, Fulakeza RMJ2, Ngeranwa JN1, Ngugi MP1 and Mburu ND1

1Department of Biochemistry and Biotechnology, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya

2Department of Basic Medical Sciences, University of Malawi, College of Medicine, P/Bag 360, Chichiri, Blantyre 3, Malawi, Kenya

*Corresponding Author:
Juma KK
Department of Biochemistry and
Biotechnology, Kenyatta University
P.O. Box 43844-00100, Nairobi, Kenya
Tel: +254 728 898233
Email address: [email protected]

Received date: June 24, 2015 Accepted date: July 10, 2015 Published date: July 15, 2015

Citation: Juma KK, Fulakeza RMJ, Ngeranwa JN, Ngugi MP, Mburu ND (2015) Evidence Based Phytopharmacological Potential of Herbal Extracts in Post-Ingestion Management of Mycotoxins in Animal Models. J Clin Toxicol 5:260. doi:10.4172/2161-0495.1000260

Copyright: © 2015 Juma KK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aflatoxins and ochratoxins are common mycotoxic food poisons and acute doses are responsible for causing liver and kidney damage and hepatocarcinoma. The strategy for managing mycotoxins has mainly been pre-ingestive. However, few solutions have been proposed for post-ingestion management and likewise there is no antidote for managing the condition. Studies have demonstrated that Saccharomyces cerevisiae and herbal extracts have potential of limiting the damage caused by reactive oxygen species and toxic effects associated with mycotoxins. Further evidence also shows that herbal extracts provides protection to a variety of cancer cell lines associated with mycotoxins. This study therefore examines the probable potential and options of using medicinal herbal extracts, on their own or in combinations with Saccharomyces cerevisiae, in the management of mycotoxicosis. A combination of the two has potential to offer a multifunctional approach in the management of post ingested mycotoxins such as aflatoxins and ochratoxins.

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