alexa Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses
ISSN: 2378-5756

Journal of Psychiatry
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Research Article

Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses

George B Stefano* and Richard M Kream

MitoGenetics Research Institute, 3 Bioscience Park Drive, Suite 307, Farmingdale, NY 11735, USA

*Corresponding Author:
George B Stefano
MitoGenetics Research Institute
3 Bioscience Park Drive, Suite 307
Farmingdale, NY 11735
Tel: 6312273930
E-mail: [email protected]

Received Date: July 31, 2015; Accepted Date: September 21, 2015; Published Date: September 29, 2015

Citation: Stefano GB, Kream RM (2015) Evolutionary Perspective on Microglial/ Neuronal Coupling with Special Relevance to Psychiatric Illnesses. J Psychiatry 18:329. doi:10.4172/2378-5756.1000329

Copyright: © 2015 Stefano GB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Microglia have selectively evolved as a morphologically and chemically distinct class of immuno-competent CNS resident cells with potent bidirectional signaling capabilities linked to induction of a macrophage-like phenotype following metabolic, microbiological, or viral insults. It has been empirically determined that a conserved set of shared chemical messengers connects a communication network mediating reciprocal exchange of regulatory information between immune, central nervous, and neuroendocrine systems. From an evolutionary perspective, the pluripotent neuro-protective capabilities of invertebrate microglia have been extended and amplified in classes of mammalian microglia. The state-dependent plasticity of microglia has provoked considerable empirical investigation into their functional/regulatory roles in mediating innate immune surveillance and neural protection within the CNS. Upon pathophysiological dysregulation, aberrant microglial activities may provide significant contributory factors in the etiology and persistence of major neurological, degenerative, and psychiatric disorders. Within this context, invertebrate microglia appear to represent highly appropriate model systems to investigate underlying cellular and molecular mechanisms involved in higher order neuroimmune regulation of multiple CNS activities by mammalian microglia


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