alexa Evolving Evidence of Methylglyoxal and Dicarbonyl Stress Related Diseases from Diabetic to Non-Diabetic Models
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Short Article

Evolving Evidence of Methylglyoxal and Dicarbonyl Stress Related Diseases from Diabetic to Non-Diabetic Models

Wen-Chuang Wang1, Jen-Ai Lee2* and Chu-Kuang Chou3,4*

1Department of Pathology, Chia-Yi Christian Hospital, Jhongsiao Rd., Chia-Yi City 60002, Taiwan

2School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan

3Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chia-Yi Christian Hospital, Chia-Yi City 60002, Taiwan

4Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan

*Corresponding Authors:
Jen-Ai Lee
School of Pharmacy, College of Pharmacy
Taipei Medical University, No. 250, Wuxing St. Taipei 11031, Taiwan, R.O.C
Tel: 886- 2-2736-1661 Ext. 6125
Fax: 886-2-2736-1661 Ext. 6120
E-mail: [email protected]
 
Chu-Kuang Chou
Division of Gastroenterology and Hepatology, Chia-Yi Christian Hospital
No.539, Jhongsiao Rd., Chia-Yi City 60002, Taiwan, R.O.C
Tel: 886-5- 276-5041 Ext. 65282
Fax: 886-5-276-5041 Ext. 65282
E-mail: [email protected]

Received Date: March 25, 2016; Accepted Date: April 19, 2016; Published Date: April 22, 2016

Citation: Wang WC, Lee JA, Chou CK (2016) Evolving Evidence of Methylglyoxal and Dicarbonyl Stress Related Diseases from Diabetic to Non-Diabetic Models. Pharm Anal Acta 7:473. doi: 10.4172/2153-2435.1000473

Copyright: © 2016 Wang WC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Methylglyoxal (MGO), a byproduct of sugar and lipid metabolic processes, is a major glycating agent. This metabolite reacts with basic residues of proteins and promotes the formation of advanced glycation end products (AGEs). Although MGO and AGEs are widely discussed in the context of diabetes, until recently, MGO was thought to result from insufficient blood sugar control. A new report reveals that plasma MGO, and not blood sugar, distinguishes diabetic patients with no pain from those with pain. This ability brings to MGO a new applicability to disease diagnosis. Diseases with normal sugar conditions, such as hypertension, sepsis, and renal disease, are increasingly recognized as MGO-related. We review the role of MGO in drug-induced nephropathy, induction of hypertension by oral administration, and as a biomarker of sepsis. We also discuss the measurement of MGO and its stable metabolite d-lactate. The metabolism and pathogenic mechanisms of MGO need investigation in diverse disease models. Whether MGO can be considered as an individual pathological factor will be an interesting topic.

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