alexa Excessive Intake Salt Contribution to Cognitive Impairment in Mice | OMICS International| Abstract

ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research

  • Research Article   
  • J Mol Pharm Org Process Res 3: 124,
  • DOI: 10.4172/2329-9053.1000124

Excessive Intake Salt Contribution to Cognitive Impairment in Mice

Yu LJ1#, Wan P3#, Wang D1, Bian M1, Bao SY1 and GONG GH1,2*
1Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, PR China
2Affiliated Hospital of Inner Mongolia University for Nationalities, , Tongliao, Inner Mongolia, PR China
3Teaching and Research Department of Physiology, Jilin medical college, , Jilin, PR China
#Contributed equally to this work
*Corresponding Author : GONG GH, Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, No. 1742 Holin He Street, Tongliao City, Inner Mongolia, Autonomous Region, 028007, PR China, Tel: +86-0475-8314234, Email: [email protected]

Received Date: Mar 05, 2015 / Accepted Date: Apr 15, 2015 / Published Date: Apr 22, 2015

Abstract

Dementia mice model was prepared by D-gal, Morris water maze was used for behavior research; c(WB) method was used for the pre-dementia protein expression research. Results showed that excessive intake of salt significantly decreased the memory ability and significantly prolonged the escape time and distance to get the platform; WB results showed that expressions of beta amyloid (Aβ) and β-site APP cleaving enzyme 1 (BACE1) significantly increased and the NEP expression significantly decreased under the condition of excessive salt intake. Results suggest that excessive salt intake can regulate the protein expressions of Aβ, BACE1 and neprilysin to enhance D-gal-induced dementia.

Keywords: Edible salt; D-gal; Aging; Dementia

Citation: Gong GH, Xi Wei C, Wang D, Bian M, Bao SY, et al. (2015) Excessive Intake Salt Contribution to Cognitive Impairment in Mice. J Mol Pharm Org Process Res 3: 124 Doi: 10.4172/2329-9053.1000124

Copyright: ©2015 Gong GH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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