Excessive Intake Salt Contribution to Cognitive Impairment in Mice
Received Date: Mar 05, 2015 / Accepted Date: Apr 15, 2015 / Published Date: Apr 22, 2015
Dementia mice model was prepared by D-gal, Morris water maze was used for behavior research; c(WB) method was used for the pre-dementia protein expression research. Results showed that excessive intake of salt significantly decreased the memory ability and significantly prolonged the escape time and distance to get the platform; WB results showed that expressions of beta amyloid (Aβ) and β-site APP cleaving enzyme 1 (BACE1) significantly increased and the NEP expression significantly decreased under the condition of excessive salt intake. Results suggest that excessive salt intake can regulate the protein expressions of Aβ, BACE1 and neprilysin to enhance D-gal-induced dementia.
Keywords: Edible salt; D-gal; Aging; Dementia
Citation: Gong GH, Xi Wei C, Wang D, Bian M, Bao SY, et al. (2015) Excessive Intake Salt Contribution to Cognitive Impairment in Mice. J Mol Pharm Org Process Res 3: 124 Doi: 10.4172/2329-9053.1000124
Copyright: ©2015 Gong GH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 12316
- [From(publication date): 8-2015 - Nov 22, 2018]
- Breakdown by view type
- HTML page views: 8507
- PDF downloads: 3809