Exclusive and Common Subsets of Zika Virus Polyprotein MutantsJoel K Weltman*
Emeritus of Medicine, Alpert Medical School, Brown University, USA
- *Corresponding Author:
- Joel K Weltman
Clinical Professor Emeritus of Medicine Alpert Medical School
Brown University Providence, RI 02912, USA
E-mail: [email protected]
Received date: May 02, 2017; Accepted date: June 01, 2017; Published date: June 07, 2017
Citation: Weltman JK (2017) Exclusive and Common Subsets of Zika Virus Polyprotein Mutants. J Med Microb Diagn 6:256. doi:10.4172/2161-0703.1000256
Copyright: © 2017 Weltman JK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Two subsets of Zika virus (ZIKV) polyprotein amino acid positions are identified. One subset (Exclusive) consists of mutating amino acid positions which were found only in polyproteins isolated from ZIKV of human origin. A second subset (Common) consists of mutating amino acid positions which were found both in ZIKV polyproteins of human origin and in ZIKV polyproteins of Aedes species mosquito origin. The dominance of the Exclusive subset in the polyprotein was found to range from the N-terminus structural proteins until non-structural protein NS3. Although no longer greater than the Common subset, elements of the Exclusive subset existed almost to the C-terminus of non-structural protein NS5. These results are considered in the context of reported epitopic and other biological characteristics of ZIKV.