Exercise as a Protective Cardiovascular Factor in ESRD Patients
Myriam Isnard-Rouchon* and Céline Coutard
AURA Auvergne, Chamalières, France
- *Corresponding Author:
- Myriam Isnard-Rouchon
Nephrologist, AURA Auvergne
8 rue du Colombier, Chamalières
E-mail: [email protected]
Received Date: October 02, 2015; Accepted Date: October 24, 2015; Published Date: October 31, 2015
Citation: Isnard-Rouchon M, Coutard C (2015) Exercise as a Protective Cardiovascular Factor in ESRD Patients. J Nephrol Ther 5:219. doi:10.4172/2191-0959.1000219
Copyright: © 2015 Isnard-Rouchon M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: The aim of the study was to show the effectiveness of Physical Activity (PA) during dialysis as a protective treatment against cardiovascular (CV) diseases.
Methods: Eighty volunteer patients were included in this multicentric prospective study and followed for one year: 40 patients in the Exercise group (EX), 40 patients in the Control group (CON). CV risk factors: Total Cholesterol, HDL Cholesterol (HDL-c), LDL cholesterol (LDL-c), Triglycerides (TG) and Hemoglobin (Hb), were checked. The number of antihypertensive treatments and the Erythropoietin Stimulating Agent (ESA) required doses were collected. We noted for each group during the follow-up the number of hospitalizations for CV reasons.
Results: We observed a slight decrease of total cholesterol in both groups, more important for EX (1.82 ± 0.47 at M0 (Month 0), 1.74 ± 0.51 at M12 (Month 12) than for CON (1.60 ± 0.26 at M0; 1.63 ± 0.45 at M12). HDL-c increased in both groups, but LDL-c decreased in EX and increased in CON. The TG decreased in both groups after one year. The Hb level remained more stable in the EX group (11.70 ± 1.17 to 12.06 ± 1.11, p < 0.05) than in the CON group (11.79 ± 1.01 (M0) and 11.35 ± 1.21 (M12)). There was a significant difference between EX and CON at M12 (respectively 12.06 ± 1.11 vs. 11.35 ± 1.21). At the same time, the required doses of Erythropoietin Stimulating Agent (ESA) decreased in EX and increased in CON. The number of antihypertensive drugs per patient decreased significantly (p < 0.05) in the EX group between M0 and M12 (1.85 ± 1.08 at M0 and 1.55 ± 0.85 at M12). The EX patients were 3 times less frequently hospitalized for cardiovascular reasons. There were 3 hospital stays versus 20 for the CON group.
Conclusion: Our study demonstrates that an intradialytic aerobic cycling training program promotes beneficial effects on cardiovascular protection: Lipids control, HTA control and Hb stability. Physical Activity although reduced the CV events in our population during one year follow-up.