alexa Exercise-Induced Inflammatory Response: To Use or Not u
ISSN: 2161-0673

Journal of Sports Medicine & Doping Studies
Open Access

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Review Article

Exercise-Induced Inflammatory Response: To Use or Not use Anti-Inflammatory Medication

Albená Nunes-Silva1,2*

1Laboratório de Resolução da Resposta Inflamatória do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brasil

2Instituto de Ensino e Pesquisa (IEP), Hospital Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brasil

*Corresponding Author:
Albená Nunes-Silva
Rua Major Lopes nº 738 – apto 601 –
Bairro São Pedro – Belo Horizonte –
Minas Gerais – Brasil, CEP 30330-050
Tel: 31-9992-3426
E-mail: [email protected]

Received Date: April 23, 2014; Accepted Date: June 25, 2014; Published Date: July 10, 2014

Citation: Nunes-Silva A (2014) Exercise-Induced Inflammatory Response: To Use or Not use Anti-Inflammatory Medication. J Sports Med Doping Stud 4:142. doi: 10.4172/2161-0673.1000142

Copyright: © 2014 Nunes-Silva A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Intense exercise is a physiological stress capable of inducing damage in the exercised muscle group. As a consequence of this exercise-induced micro lesion, there is an increase in the interaction of leukocytes (neutrophils and monocytes/macrophages) with muscle endothelial cells and their transmigration into skeletal muscle tissue. Mechanisms driving this physiological response are not known, but exercise-induced muscle damage may be associated with a local inflammation involving leukocyte accumulation in damaged muscle tissue. Important recent findings show that this infiltration of leukocytes plays an important role in the skeletal muscle remodeling process by activating angiogenesis and hypertrophic pathways inside the skeletal muscle tissue. There are some speculations suggesting that this inflammatory process should be controlled by anti-inflammation drugs in athletes to accelerate the recovery time. Investigations of the literature in this field up to this point do not offer a sufficient body of evidence confirming the need for an anti-inflammatory drug administration to control the exercise-induced inflammation. On the other hand, anti-inflammatory drug administration as a supplemental diet could inhibit important pathways of tissue adaptative responses and block the benefits of exercise to the skeletal muscle tissue.


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