alexa Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies

Angelo Andriulli1*, Antonio Massimo Ippolito1, Virginia Festa2, Maria Rosa Valvano1, Antonio Merla1, Fabrizio Bossa1, Grazia Niro1, Grazia Napolitano1, Luigi Benini3 and Italo Vantini3

1Divisions of Gastroenterology, “Casa SollievoSofferenza” Hospital, IRCCS, Italy

2“San Filippo Neri” Hospital, Roma, Italy

3Chair of Gastroenterology, Universityof Verona, Italy

*Corresponding Author:
Angelo Andriulli
Division of Gastroenterology
“Casa SollievoSofferenza” Hospital
San Giovanni Rotondo, Italy
Tel: +39 0882 410263
Fax: +39 0882 835411
E-mail: [email protected]

Received date: April 19, 2014; Accepted date: May 27, 2014; Published date: May 30, 2014

Citation: Andriulli A, Ippolito AM, Festa V, Valvano MR, Merla A, et al. (2014) Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies. J Diabetes Metab 5:379. doi: 10.4172/2155-6156.1000379

Copyright: © 2014 Andriulli A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: To assess the prevalence of pancreatic exocrine insufficiency (PEI) inpatients with diabetes mellitus (DM).

Design: Meta-analysis of prospective, observational studies that used fecal elastase-1 estimation to determine PEI in patients with DM.

Data extraction: A total of 11 studies out of 1156 retrieved references, published between 2000 and 2013, fulfilled the inclusion criteria. The primary outcome measure was proportions of patients with DM and PEI.

Results: Of the 2891 patients enrolled, 921 (31.8%) showed abnormal (i.e, <200 μg/g) fecal elastase-1 excretion. Prevalence of PEI varied across studies, with figures ranging from 5% to 57%. After pooling rates from individual reports, a weighted prevalenceof 31.6% with 95% confidence intervals (CI) of 24.8-39.3 was estimated. Of the 906 patients with abnormal fecal elastase-1, half had severe (<100 μg/g) and half a mild to moderate impairment (>100 but <200 μg/g) in elastase-1 excretion. In 921 patients with type-1 DM, the weighted rate of PEI was 37.7% (CI 27.2-49.5), and 26.2% (CI 19.4-34.3) in 1970 type-2 diabetic patients, a difference of 11.5% (p=0.09). Of patients with abnormal (<200 μg/g) fecal elastase-1 concentrations, severe PEI was present in 53.4% (CI 45.2-61.4) of type-1, and in 50.3% (CI 40.7-59.9) of type-2 diabetic patients.

Limitation: Some variables, which may influence fecal elastase-1 excretion, could not be controlled due to missing data. Conclusions: When explored by fecal elastase-1 testing, one in three patients with DM showed signs of impaired exocrine function. The results suggest that testing for PEI should be part of the diagnostic work-up of patients with DM.


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