alexa Expanding the Targets of Renal Sympathetic Denervation: From Resistant Hypertension to Atrial Fibrillation | OMICS International | Abstract
ISSN: 2167-1095

Journal of Hypertension: Open Access
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Review Article

Expanding the Targets of Renal Sympathetic Denervation: From Resistant Hypertension to Atrial Fibrillation

Spyridon Koulouris*

II Clinic of Cardiology, Angiology, Pneumology and Intensive Care Medicine, Germany

*Corresponding Author:
Spyridon Koulouris
II Clinic of Cardiology, Angiology
Pneumology and Intensive Care Medicine
Klinikum Bayreuth GmbH, 101 Preuschwitzer Str
95445 Bayreuth, Germany
Tel: 004992115123895
E-mail: [email protected]

Received Date: July 26, 2013; Accepted Date: August 21, 2013; Published Date: August 23, 2013

Citation: Koulouris S (2013) Expanding the Targets of Renal Sympathetic Denervation: From Resistant Hypertension to Atrial Fibrillation. J Hypertens 2:123. doi:10.4172/2167-1095.1000123

Copyright: © 2013 Koulouris S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Atrial fibrillation is the most common cardiac arrhythmia affecting millions of people worldwide. Individuals with atrial fibrillation sustain significant morbidity mainly due to stroke while their mortality risk is twice higher in comparison to those with sinus rhythm. During the recent years radiofrequency ablation has become a standard procedure for the treatment of atrial fibrillation, albeit with moderate efficacy. Among the risk factors of atrial fibrillation, hypertension has a prominent role. Recently Renal Sympathetic Denervation has been proposed as an effective way to control resistant hypertension showing a sustained reduction in blood pressure. Increased sympathetic activity seems necessary to induce and sustain atrial fibrillation. It can also be considered as one of the common pathways connecting hypertension with atrial fibrillation. Given the limitations of the conventional treatment of atrial fibrillation, Renal Sympathetic Denervation has been proposed as a new treatment modality for the management of this common arrhythmia. Hard data are still lacking but the early results are very promising. Two randomized trials are currently conducted and are expected to answer the question whether the targets of Renal Sympathetic Denervation can expand beyond the treatment of resistant hypertension.

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