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Experiences in Hepatic Surgery and Transplantation after Radioembolization | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Special Issue Article

Experiences in Hepatic Surgery and Transplantation after Radioembolization

Giuseppe Maria Ettorre1*, Giovanni Vennarecci1, Roberto Santoro1, Lucia Miglioresi1, Pasquale Lepiane1, Marco Colasanti1, Enrico Moroni1, Andrea Laurenzi1, Lidia Colace1, Rosa Sciuto2, Livio Carpanese3 and Mario Antonini4

1Liver Transplantation and General Surgery Unit, San Camillo Hospital, Rome, Italy

2Nuclear Medicine, Regina Elena Cancer Institute Rome, Italy

3Interventional Radiology, Regina Elena Cancer Institute Rome, Italy

4Anestesiology and ICU, National Institute of Infectious Disease, Rome, Italy

*Corresponding Author:
Giuseppe Maria Ettorre MD
Liver Transplantation and General Surgery Unit
San Camillo Hospital, Rome, Italy. Gianicolense 87
00152, Roma, Italy
Tel: +39 06 58704816
Fax: +39 06 58704719
E-mail: [email protected]

Received date: April 26, 2011; Accepted date: May 26, 2011; Published date: June 15, 2011

Citation: Ettorre GM, Vennarecci G, Santoro R, Miglioresi L, Lepiane P, et al. (2011) Experiences in Hepatic Surgery and Transplantation after Radioembolization. J Nucl Med Radiat Ther 2:109. doi:10.4172/2155-9619.1000109

Copyright: © 2011 Ettorre GM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Yttrium-90 microspheres radioembolization has shown to be an effective modality of treatment in patients with primary or metastatic liver tumours [1-4]. It is usually offered to patients with advanced liver cancers. However, surgical experience after radioembolization is very limited to anecdotal cases mainly related to hepatocellular carcinoma. We have treated patients with hepatocellular carcinoma or liver metastasis mainly from colon, breast, melanoma and neuroendocrine tumours. In our experience after such treatment we were able to downstage the tumour to surgery only in the case of hepatocellular carcinoma. Five patients had liver transplantation and 1 had right hepatic resection after Yttrium-90 microspheres radioembolization. Of note 2 patients had neoplastic infiltration of a portal vein branch which resolved after treatment with Yttrium-90 microspheres radioembolization. The extra-hepatic spread was ruled out and later they were both transplanted. Here we report our initial single center experience with Yttrium-90 microspheres radioembolization as downstaging and bridging method for hepatocellular carcinoma prior liver surgery, resection or liver transplantation.


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