alexa Experimental Phage Therapy on Multiple Drug Resistant Pseudomonas aeruginosa Infection in Mice | OMICS International | Abstract
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Experimental Phage Therapy on Multiple Drug Resistant Pseudomonas aeruginosa Infection in Mice

Zhabiz Golkar1*, Omar Bagasra1 and Nusrat Jamil2

1South Carolina Center for Biotechnology, Department of Biology, Claflin University, USA

2Department of Microbiology, University of Karachi, Pakistan

*Corresponding Author:
Zhabiz Golkar, PhD
South Carolina Center for Biotechnology
Department of Biology, Claflin University
400 Magnolia Street, Orangeburg, SC 29115, USA
Tel: (803)-535-5502
E-mail: [email protected]; [email protected]

Received Date: October 25, 2013; Accepted Date: November 27, 2013; Published Date: November 30, 2013

Citation: Golkar Z, Bagasra O, Jamil N (2013) Experimental Phage Therapy on Multiple Drug Resistant Pseudomonas aeruginosa Infection in Mice. J Antivir Antiretrovir S10:005. doi: 10.4172/jaa.S10-005

Copyright: © 2013 Jain SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

With the rising prevalence of multiple-antibiotic resistant-bacteria (MDRs) and the lack of development of new antibiotics by the pharmaceutical industries, there is an urgent need to develop novel approaches to combat MDRs, especially Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. Bacteriophage therapy has been applied for decades as a means of treating bacterial infections in some parts of the world and numerous encouraging results have been documented. Here, we present evidence in murine models that animals infected with MDRs P. aeruginosa can be successfully treated with specific bacteriophages that target these MDRs microbes. We utilized three different forms of bacterial infections on Stage II and III wound on deep lower back of animals; deep wound infection and chronic infection treated the each of the infections by respective dermal application of phages. Furthermore, we successfully tested phage therapy for both acute and chronic infections. We evaluate the potential use of lytic phage on wound contraction; we observed drastic changes on the wounds after 24-hours of phage application. Pros and cons of phage therapy to treat human MDRs are discussed.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7