alexa Experimental Phage Therapy on Multiple Drug Resistant Pseudomonas aeruginosa Infection in Mice
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

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Research Article

Experimental Phage Therapy on Multiple Drug Resistant Pseudomonas aeruginosa Infection in Mice

Zhabiz Golkar1*, Omar Bagasra1 and Nusrat Jamil2

1South Carolina Center for Biotechnology, Department of Biology, Claflin University, USA

2Department of Microbiology, University of Karachi, Pakistan

*Corresponding Author:
Zhabiz Golkar, PhD
South Carolina Center for Biotechnology
Department of Biology, Claflin University
400 Magnolia Street, Orangeburg, SC 29115, USA
Tel: (803)-535-5502
E-mail: [email protected]; [email protected]

Received Date: October 25, 2013; Accepted Date: November 27, 2013; Published Date: November 30, 2013

Citation: Golkar Z, Bagasra O, Jamil N (2013) Experimental Phage Therapy on Multiple Drug Resistant Pseudomonas aeruginosa Infection in Mice. J Antivir Antiretrovir S10:005. doi: 10.4172/jaa.S10-005

Copyright: © 2013 Jain SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

With the rising prevalence of multiple-antibiotic resistant-bacteria (MDRs) and the lack of development of new antibiotics by the pharmaceutical industries, there is an urgent need to develop novel approaches to combat MDRs, especially Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. Bacteriophage therapy has been applied for decades as a means of treating bacterial infections in some parts of the world and numerous encouraging results have been documented. Here, we present evidence in murine models that animals infected with MDRs P. aeruginosa can be successfully treated with specific bacteriophages that target these MDRs microbes. We utilized three different forms of bacterial infections on Stage II and III wound on deep lower back of animals; deep wound infection and chronic infection treated the each of the infections by respective dermal application of phages. Furthermore, we successfully tested phage therapy for both acute and chronic infections. We evaluate the potential use of lytic phage on wound contraction; we observed drastic changes on the wounds after 24-hours of phage application. Pros and cons of phage therapy to treat human MDRs are discussed.

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