Experimental Study on Holoptelia Integrifolia Planch. in Relation to Diabetes Mellitus Type 2
Holoptelea integrifolia (Ulmaceae) is a very important medicinal plant used in various indigenous systems of medicine for curing several diseases, diabetes mellitus is one of them. It is traditionally used in the treatment and prevention of several ailments like leprosy, inflammation, rickets, leucoderma, scabies, rheumatism, ringworm, eczema, malaria, intestinal cancer, and chronic wounds. In experimental study it was found that it has no toxic effect alongwith it has no hypoglycemic effect in normoglycemic rats. In Streptozotocin and hydrocortisone induced hyperglycemic rats the hypoglycemic activity of the drug was found highly significant. So this drug seems to be very rationale for the treatment of Diabetes mellitus. It has also antibacterial, antifungal, analgesic, antioxidant, anti-inflammatory, anthelmintic, antidiabetic, antidiarrhoeal, adaptogenic, anticancer, wound healing, hepatoprotective, larvicidal, antiemetic, CNS depressant, and hypolipidemic activities. This drug works on diabetes mellitus according to Ayurveda by its properties like it has Tikta, Kashaya Rasa, Laghu. Ruksha Guna, Ushna Virya and Katu Vipaka it subsides the Kaphapitta Dosha. So it is also helpful in following diseases like Shotha, Agni mandya, Chhardi, Udararoga, Shoola, Gulma, Arsha, Krimi, Raktavikara, Prameha, Kushtha, Charmaroga, Medoroga. So inspite of treating only Prameha it is used as a multipurpose drug also for curing several diseases.