alexa Exploration of the Protective Effects of Some Natural Compounds against Neurodegeneration Exploiting Glycine Receptors in vivo Model | OMICS International | Abstract
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Exploration of the Protective Effects of Some Natural Compounds against Neurodegeneration Exploiting Glycine Receptors in vivo Model

Raafat KM*
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, Lebanon;
Corresponding Author : Raafat KM
Department of Pharmaceutical Sciences
Faculty of Pharmacy, Beirut Arab University
115020 Beirut, Lebanon
Tel: +961-76014620
E-mail: [email protected]
Received July 25, 2013; Accepted August 12, 2013; Published August 19, 2013
Citation: Raafat KM (2013) Exploration of the Protective Effects of Some Natural Compounds against Neurodegeneration Exploiting Glycine Receptors in vivo Model. Nat Prod Chem Res 1:113. doi: 10.4172/2329-6836.1000113
Copyright: © 2013 Raafat KM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The commencement of the presented project was by screening of natural compounds extracted from neuroactive endogenous medicinal plants. Explicitly, ferutinin (Ferula hermonis L.), thymoquinone (Nigella sativa L.), eugenol (Syzygium aromaticum L.) and 6-gingerol (Zingiber officinale L.) were tested for their protective effect against neurodegeneration utilizing Glycine receptors (GlyRs) in vivo model. None of these compounds were reported before to modulate the in vivo GlyRs. GlyRs are inhibitory key mediators of synaptic signaling in spinal cord, brain stem, and higher central nervous system regions. Neurodegeneration may cause alteration of the GlyRs causing strychnine-like convulsions and stiffness. Modulation of GlyRs in vivo was studied in a mouse model of strychnine toxicity. Ferutinin revealed to be potent modulators to GlyR; with potential anticonvulsant properties in low doses. Thymoquinone, eugenol and 6-gingerol when given together with strychnine, in low concentrations reduce strychnine toxicity by reversing strychnine toxicity in mice. It could be concluded that all compounds under investigation could be used as sedatives in low doses. In order to fight against neurodegenerative diseases is to improve body antioxidant, the compounds under investigation provided to be good sources for antioxidant potential. In brief, ferutinin, thymoquinone, eugenol and 6-gingerol suggested being novel GlyR modulators, good phytochemicals, pharmacological tool and a dose sensitive drug to treat stiffness, convulsions and prophylactic agents to guard against neurodegenerative disorders.

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