Exposure to Environmental Tobacco Smoke during Pregnancy Restrain the Antioxidant Response of their Neonates
|Abdullah Kurt1*, Ayşegü Nese Citak Kurt2, Derya Benzer3, Abdullah Denizmen Aygün4, Bilal Ustündag5, Yasar Dogan3 and Ozcan Erel6|
|lDepartment of Pediatrics, Division of Neonatology, Ankara Medical Park Hospital University, Ankara, Turkey|
|2Department of Pediatrics Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey|
|3Department of Pediatrics, Medical Faculty of Firat University, Elazig, Turkey|
|4Department of Pediatrics, Medical Faculty of Bilim University, Istanbul, Turkey|
|5Department of Biochemistry, Medical Faculty of Firat University, Elazig, Turkey|
|6Department of Biochemistry, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey|
|Corresponding Author :||Abdullah Kurt
Departments of Pediatrics
Division of Neonatology
Ankara Medical Park Hospital University
Tel: +90 533 331 73 29
Fax: +90 (312) 666 86 66
E-mail: [email protected]
|Rec date: January 08, 2016; Acc date: January 27, 2016; Pub date: January 30, 2016|
|Citation: Kurt A, Kurt ANC, Benzer D, Aygün AD, Ustündag B, et al. (2016) Exposure to Environmental Tobacco Smoke during Pregnancy Restrain the Antioxidant Response of their Neonates. J Neonatal Biol 5:210. doi:10.4172/2167-0897.1000210|
|Copyright: © 2016 Kurt A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Purpose: Smoking during pregnancy has several effects and risks on the neonates. The aim is to assess the effects of exposure to environmental tobacco smoke during pregnancy on the antioxidant status of their neonates.
Design: In cord blood samples of 116 healthy newborns which were classified into groups according to mothers smoking status (active, passive or non-smoker), the activities of paraoxanase 1 and aryl esterase, concentrations of free sulfhydryl groups and total antioxidant response were studied using appropriate methods.
Results: Different parameters indicating antioxidant status had similar values in cord blood of term and preterm neonates of active or passive smoke or non-smoker mothers. Only, concentrations of total antioxidant response were statistically different between cord blood of neonates of active or passive smoker mothers and cord blood of term or preterm neonates of non-smoker mothers (1.12 ± 0.1, 1.10 ± 0.08 and 1.28 ± 0.12 mmol trolox equivalent/L, for term neonates, 0.95 ± 0.0, 1.07 ± 0.13 and 1.22 ± 0.02 mmol trolox equivalent/L, for preterm neonates, respectively).
Conclusions: Neonates of active or passive smoker mothers have decreased antioxidant levels in cord blood and may be exposed to an oxidative stress greater.