Expression of Canavalia gladiata lectin in leukemic cellsLaija. S. Nair1*, Mahesh. S2, Smitha L. S3, Sujathan. K3 and Remani. P3
- *Corresponding Author:
- Dr. Laija. S. Nair
Department of Botany
Government Sanskrit College
Pattambi, Palakkad, Kerala, India
E-mail: [email protected]
Received date: December 10, 2010; Accepted date: February 14, 2011; Published date: February 18, 2011
Citation: Nair LS, Mahesh S, Smitha LS, Sujathan K, Remani P (2011) Expression of Canavalia gladiata lectin in leukemic cells. J Cancer Sci Ther 3: 088-091. doi: 10.4172/1948-5956.1000066
Copyright: © 2011 Nair LS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In this study an attempt was made to find out new tissue specific lectin from the seeds of Canavalia gladiata and to investigate whether this could be used as biological markers in haematological malignancies. Lectin binding studies showed that Lymphoid leukemias such as ALL (Acute Lymphocytic Leukemia) and CLL (Chronic Lymphocytic Leukemia) cells did not show any reactivity with CGL (Canavalia gladiata lectin). Blast cells of myeloid leukemias showed varying intensities of staining. Kruskal Wallis One Way ANOVA showed significance in expression of the lectin with different types of Acute Myeloid Leukemia. Lectin cytochemical studies in leukemia revealed its usefulness in differentiating lymphoid leukemias from myeloid leukemias.