Expression of Molecular Markers in Tumours of Patients with Breast CancerD O Shapochka1*, S P Zaletok1 and M I Gnidyuk2
- *Corresponding Author:
- D.O. Shapochka
R.E. Kavetsky Institute of Experimental Pathology
Oncology and Radiobiology of NAS of Ukraine
E-mail: [email protected]
Received date: July 18, 2013; Accepted date: August 10, 2013; Published date: August 12, 2013
Citation: Shapochka DO, Zaletok SP, Gnidyuk MI (2013) Expression of Molecular Markers in Tumours of Patients with Breast Cancer. J Cytol Histol 4:184. doi:10.4172/2157-7099.1000184
Copyright: © 2013 Shapochka DO, et al. This is an open-access article distributedunder the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The expression of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67, p53, Bcl-2 and E-cadherin in tumor tissue of 132 patients with breast cancer was investigated by immunohistochemistry. As a result of researches the correlation between Grade and expression of ER, PR, Bcl-2, Ki-67 and p65-subunit of NF-κB was defined. The level of proliferation was correlated with ER, PR, Bcl-2, p53 and Her2/neu expression. Also the correlation between some of investigated markers was found. Thus, high level of NF-κB nuclear expression was associated with Her2/neu hyperexpression and negative status of ER, PR and Bcl-2. These data may indicate poor prognosis and resistance to chemotherapy in breast cancer patients with activated NF-κB, but it requires further research and retrospective analysis of large number of patients.