Journal of Clinical and Experimental Ophthalmology
Open Access

Abstract

Expression of p53 and Mdm2 in Human Retinoblastoma

Parul Saxena, Seema Kashyap, Mandeep Singh Bajaj, Neelam Pushker, Supriyo Ghose and Jasbir Kaur

Retinoblastoma (Rb) is a malignant tumor of the developing retina. Retinoblastomas arise within the retina to form soft white tumor masses that expand within the vitreous cavity of the eye, and if untreated, mostly invade through the sclera, or along the optic nerve, or hematogenously via the choroids, in turn posing a risk for metastasis. However, it is an uncommon tumor accounting for 3% of all childhood malignancies in developed countries. Very few studies on p53 expression in retinoblastoma patient’s inspite of its crucial role in tumorigenesis are officially recorded. Therefore, we detected the expression of p53 and mdm2 in retinoblastoma by immunohistochemistry, analyzed their relationships with clinicopathological parameters and then investigated the influence on the biological activity of retinoblastoma.