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Expression of p53 and Mdm2 in Human Retinoblastoma | OMICS International | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

Expression of p53 and Mdm2 in Human Retinoblastoma

Parul Saxena1, Seema Kashyap2, Mandeep Singh Bajaj3, Neelam Pushker3, Supriyo Ghose3 and Jasbir Kaur1*
1Department of Ocular Biochemistry, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
2Department of Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
3Pediatric Ophthalmology and Oculoplasty Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
Corresponding Author : Dr. Jasbir Kaur
Department of Ocular Biochemistry
Dr. Rajendra Prasad Centre for Ophthalmic Sciences
All India Institute of Medical Sciences
New Delhi-110 029, India
Tel: +91-11-26593161
Fax: +91-11-26588919
E-mail: [email protected]
Received September 21, 2010; Accepted July 26, 2012; Published July 30, 2012
Citation: Saxena P, Kashyap S, Bajaj MS, Pushker N, Ghose S, et al. (2012) Expression of p53 and Mdm2 in Human Retinoblastoma. J Clin Exp Ophthalmol 3:236 doi:10.4172/2155-9570.1000236
Copyright: © 2012 Saxena P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Retinoblastoma (Rb) is a malignant tumor of the developing retina. Retinoblastomas arise within the retina to form soft white tumor masses that expand within the vitreous cavity of the eye, and if untreated, mostly invade through the sclera, or along the optic nerve, or hematogenously via the choroids, in turn posing a risk for metastasis. However, it is an uncommon tumor accounting for 3% of all childhood malignancies in developed countries. Very few studies on p53 expression in retinoblastoma patient’s inspite of its crucial role in tumorigenesis are officially recorded. Therefore, we detected the expression of p53 and mdm2 in retinoblastoma by immunohistochemistry, analyzed their relationships with clinicopathological parameters and then investigated the influence on the biological activity of retinoblastoma.

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