Expression of Survivin Gene and Protein in Mycosis Fungoides
|Hanan Nada1,2*, Laila Rashed2 and Solafa Amin2|
|1Soliman Fakeeh Hospital, Saudi Arabia|
|2Department of Dermatology, Biochemistry and Pathology, Cairo University, Egypt|
|*Corresponding Author :||Hanan Nada
Soliman Fakeeh Hospital
Saudi Arabia and Department of Dermatology
Biochemistry and Pathology, Cairo University
Tel: 002 01023000226
E-mail: [email protected]
|Received date: Feb 17, 2016, Accepted date: Mar 29, 2016, Published date: Apr 06, 2016|
|Citation: Nada H, Rashed L, Amin S (2016) Expression of Survivin Gene and Protein in Mycosis Fungoides. J Nurs Care 5:339. doi:10.4172/2167-1168.1000339|
|Copyright: © 2016 Nada H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: Survivin is a member of the inhibitors of apoptosis gene family that has been implicated in cell division and suppression of apoptosis that becomes expressed in human cancers, e.g. colorectal, bladder cancers. But, there is no available data on the role of survivin in cutaneous neoplasms.
Aim: To estimate the expression of survivin gene and protein in Mycosis Fungoides (MF).
Methods: Seventeen cases of MF have been en-rolled into this study. Skin biopsies from such patient were subjected to RT-PCR technique to detect the level of survivin gene and protein.
Results: There was significant increase in expression of surviving gene and protein in cases of MF if compared to normal control.
Conclusion: Survivin may have a role in induction of MF and this may influence the therapeutic strategies for the treatment of MF.