Expression of Tissue Transglutaminase in Human Thyroid Cancer Cell Lines: Effect of Novel Enantiopure Triazole DerivativesMaria A Chiacchio1, Roberta Bonfanti1, Salvatore V Giofrè2, Roberto Romeo2, Mariacristina Ferrara1, Lorenzo Bandini1, Agata Campisi1* and Ugo Chiacchio1
- *Corresponding Author:
- Agata Campisi
Dipartimento di Scienze del Farmaco
Via A. Doria 6, 95125 Catania, Italy
Fax: 00390957384220; E-mail: [email protected]
Received date: July 16, 2015; Accepted date: September 10, 2015; Published date: September 14, 2015
Citation: Chiacchio MA, Bonfanti R, Giofrè SV, Romeo R, Ferrara M, et al. (2015) Expression of Tissue Transglutaminase in Human Thyroid Cancer Cell Lines: Effect of Novel Enantiopure Triazole Derivatives. Med chem 5:424-431. doi: 10.4172/2161-0444.1000295
Copyright: © 2015 Chiacchio MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A synthesis of (-)5b and (-)6d according to enzymatic resolution of racemic triazole derivatives 5b and 6d was performed with Lipozyme in 1,4-dioxane, using vinyl benzoate as the acyl donor. The effect of the compounds on TG2 overexpression in human thyroid cancer cell lines cultures at two degrees of malignancyand invasiveness was assessed. The involvement of TG2 in the activation of the apoptotic pathway is also shown. We found that the obtained compounds are able to reduce TG2 overexpression in follicular (FTC-133) and anaplastic (8305C) human thyroid cancer cell lines either in the cytosol, or in the nuclear compartment, activating also the apoptotic pathway. Our data suggest that they may represent new anticancer agents for human thyroid cancer.