Expression of Toll-like Receptor 9 in Cervical Intraepithelial Neoplasia from Mexican WomenMario Adán Moreno-Eutimio1, Gustavo Acosta-Altamirano2 and Víctor Manuel Vargas-Hernández2*
- *Corresponding Author:
- Víctor Manuel Vargas-Hernández
Dirección de Investigación
Hospital Juárez de México. Av. Instituto Politécnico Nacional 5160
Colonia: Magdalena de las Salinas. CP: 07760
Delegación: Gustavo A. Madero. México, D. F
Tel: (55) 5747 7503
E-mail: [email protected]
Received date: July 11, 2013; Accepted date: September 05, 2013; Published date: September 09, 2013
Citation: Moreno-Eutimio MA, Acosta-Altamirano G, Vargas-Hernández VM (2013) Expression of Toll-like Receptor 9 in Cervical Intraepithelial Neoplasia from Mexican Women. J Cytol Histol 4:181. doi:10.4172/2157-7099.1000181
Copyright: © 2013 Moreno-Eutimio MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: Cervical cancer is a major health problem, is the second leading cause of cancer death in women worldwide and the first in developing countries. Toll-like receptors play an important role in the immune system through the recognition of pathogen-associated molecular patterns and damage associated with endogenous molecules, so that the role of Toll-like receptors is being explored in cancer.
Objective: To evaluate the expression of Toll-like receptor 9 (TLR9) in cervical intraepithelial neoplasia grade I, II and III tissues using immunohistochemical staining.
Material and Methods: Retrospective, observational and descriptive study, the expression of TLR9 incervical intraepithelial neoplasia grade I (n=124), II (n=68) and III (n=29) tissues were evaluated using immunohistochemical staining. All samples used in this study were from Mexican women.
Results: We found the expression levels of TLR9 was higher in CIN I (p<0.001) and CIN-II (p<0.001) than in CIN-III.
Conclusion: The low expression of TLR9 may play important roles in the development and progression of cervical intraepithelial neoplasia in Mexican women.