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Expression of YKL-40, an Inflammatory Glycoprotein and its Prognostic Implications in Cancer | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Expression of YKL-40, an Inflammatory Glycoprotein and its Prognostic Implications in Cancer

Hurmale Anil Kumar*, Jatawa Suresh Kumar, Yadav Mahavir and Tiwari Archana

School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidhyalaya, Airport Bypass Road, Bhopal, India

*Corresponding Author:
Hurmale Anil Kumar
School of Biotechnology
Rajiv Gandhi Proudyogiki Vishwavidhyalaya
Airport Bypass Road, Bhopal, India
E-mail: [email protected]

Received date: May 15, 2012; Accepted date: June 15, 2012; Published date: June 19, 2012

Citation: Kumar HA, Kumar JS, Mahavir Y, Archana T (2012) Expression of YKL- 40, an Inflammatory Glycoprotein and its Prognostic Implications in Cancer. J Mol Biomark Diagn 3:130. doi:10.4172/2155-9929.1000130

Copyright: © 2012 Kumar HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


A cancer prognosticator refers to a substance or process that is a sign of the existence of cancer in the body and foretelling the course of cancer. It might be either a molecule oozed by a tumor or it can be a specific response of the body to the occurrence of cancer. YKL-40 is an inflammatory glycoprotein and a member of mammalian chitanaselike proteins (CHI3L1), is expressed and secreted by several types of solid tumor cells, inflammatory cells and stem cells. The precise physiological role of YKL-40 in cancer is not still clear and suggested that it has a role in cancer cell proliferation, differentiation, metastatic potential, cell attachment and migration, reorganization and tissue remodeling. Several clinical studies of patients with diverse types of cancer indicated that elevated serum level of YKL-40 may be a prognostic marker of cancer. The higher level of YKL-40 in serum also seems to correlate with short survival and poorer prognosis of several cancers including breast, ovary, colorectal, and glioblastoma melanoma. Serum YKL-40 level is often elevated compared to healthy subjects, in patients with disease characterized by inflammation, and increased extracellular remodeling or ongoing fibrosis such as infections. This review depict the present facts regarding YKL-40 and talk about its relation in cancer prediction


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