alexa Extended Spectrum Beta- Lactamases: A Minireview of Cli
ISSN: 2161-0703

Journal of Medical Microbiology & Diagnosis
Open Access

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Review Article

Extended Spectrum Beta- Lactamases: A Minireview of Clinical Relevant Groups

Rebecca Sullivan1,3*, David Schaus1, Michael John1,2 and Johannes A. Delport1,2

1Division of Microbiology, Pathology and Laboratory Medicine, London Health Sciences, London, Ontario, Canada

2Schulich School of Medicine, Western University, London, Ontario, Canada

3Wilfrid Laurier University, Waterloo, Ontario, Canada

*Corresponding Author:
Rebecca Sullivan
Division of Microbiology, Pathology and Laboratory Medicine
London Health Sciences, London, Ontario, Canada
Tel: 1 519-685-8500
E-mail: [email protected]

Received Date: August 20, 2015 Accepted Date: October 10, 2015 Published Date:October 13, 2015

Citation: Sullivan R, Schaus D, John M, Delport JA (2015) Extended Spectrum Beta- Lactamases: A Minireview of Clinical Relevant Groups. J Med Microb Diagn 4:203. doi: 10.4172/2161-0703.1000203

Copyright: © 2015 Sullivan R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Extended spectrum beta-lactamases are enzymes that hydrolyze the beta-lactam ring of Beta-lactam antibiotics rendering the organism resistant. ESBL prevalence is still increasing across the globe and have been implicated in hospital acquired infections and complicated urinary tract infections in Canada. TEM, SHV and CTX-M are becoming more common with CTX-M becoming more of importance as it is associated with complicated urinary tract infections. A variety of detection methods can be used including phenotypical methods, molecular methods and automated methods. Several automated instruments are commercially available to detect phenotypic resistance, recently the Clinical Laboratory Standards Institute has altered their breakpoints negating the necessity to perform confirmatory tests. Unfortunately not all of the commercial panels have the ability to detect lower breakpoints. Due to the importance of ESBL producing organisms in both hospital and community acquired infections, the associated increase in cost treating this infections and expanding spread across the globe, there is a need for further research into these enzymes.


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