alexa Extent of Under Reporting of Adverse Drug Reactions (ADRs) in India: Evaluation using Logistic Regression Analysis (LRA) Model
ISSN: 2167-0870

Journal of Clinical Trials
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Extent of Under Reporting of Adverse Drug Reactions (ADRs) in India: Evaluation using Logistic Regression Analysis (LRA) Model

Mala Kharkar1* and Suresh Bowalekar2
1Vice Principal, Patkar and Varde College, Mumbai, India
2Ex-Managing Director, Pharma Net Clinical services Pvt. Ltd, Mumbai, India
Corresponding Author : Mala Kharkar
Vice Principal, Patkar and Varde College
Goregaon (west), Mumbai, India
Tel: 9869487770
E-mail: [email protected]
Received January 22, 2014; Accepted February 17, 2014; Published February 19, 2014
Citation: Kharkar M, Bowalekar S (2014) Extent of Under Reporting of Adverse Drug Reactions (ADRs) in India: Evaluation using Logistic Regression Analysis (LRA) Model. J Clin Trials 4:155. doi:10.4172/2167-0870.1000155
Copyright: © 2014 Kharkar M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: 1. To determine
a. Statistically, the Knowledge, Attitude and Practice (KAP) related variables responsible for underreporting of ADRs in
India, using Logistic Regression Analysis (LRA) Model,
b. Extent of under reporting of ADRs at the current KAP levels of Medical Practitioners (MPs).
2. To recommend measures at National level to reduce underreporting of ADRs
Methods: The results of survey on KAPs of MPs in India towards underreporting of ADRs were published. In the survey, the information was provided on number of ADRs observed during medical practice and number of ADRs reported to ADR monitoring center by 116 MPs. MPs reported less than 25% of ADRs was assumed to contribute to underreporting. Thus, dependent variable ‘underreporting’ was measured on binary scale as ‘Yes’ or ‘No’. Similarly, six independent variables were also measured on a binary scale as ‘Yes’ or ‘No’. The six 2×2 contingency tables were prepared with ‘underreporting’ as dependent variable and each of the 6 independent variables. However, contingency table assumes the levels of all other independent variables to be the same, which is unrealistic and thus fails to estimate the true odds ratio. Hence, Logistic Regression Analysis was used to analyze the data.
Results: 2×2 contingency tables revealed that each independent variable was significantly associated with ‘underreporting’. The odds ratio was statistically significant with all six variables. Stepwise LRA applied to data of 116 MPs, picked up 4 variables as statistically significant (P<0.05).
Conclusion: At the current level of KAP of MPs, there is high probability of continuing the problem of underreporting of ADRs. To reduce the rate of underreporting it is recommended to develop appropriate training modules at National level to create awareness among all healthcare professionals and design simple ADR forms and procedures for ADR reporting.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

om[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version