alexa Extracellular Vesicles Facilitate the Intercellular Com
ISSN: 2168-9296

Cell & Developmental Biology
Open Access

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Mini Review

Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury

Heedoo Lee1, Duo Zhang1, Jasleen Minhas2 and Yang Jin1*

1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, USA.

1Internal Medicine, North Shore Medical Center, Salem Hospital, 81 Highland Ave, Salem, USA.

*Corresponding Author:
Yang Jin
Division of Pulmonary and Critical Care
Department of Medicine
Boston University Medical Campus
72 East Concord St., Boston, MA 02118, USA
Tel: 6174143291
E-mail: [email protected]

Received Date: June 13, 2016; Accepted Date: June 30, 2016 ; Published Date: July 07, 2016

Citation: Lee H, Zhang D, Minhas J, Jin Y (2016) Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury. Cell Dev Biol 5:175. doi:10.4172/2168-9296.1000175

Copyright: © 2016 Lee H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Extracellular vesicles (EVs) are a group of heterogeneous, nano-sized structures surrounded by lipid bilayer membranes that are released by cells. Depending on their size and mechanisms of formation, EVs are often referred to as exosomes, microvesicles (MVs) and apoptotic bodies (AB). EVs are evolutionally conserved vesicles that mediate intercellular communications and cross-talk, via transferring proteins, lipids and nucleic acids. Accumulating evidence suggests that EVs exert essential physiological and pathological functions on both their mother and recipient cells. Therefore, growing interests focus on the potentials of EVs to serve as novel targets for the development of therapeutic and diagnostic strategies. Currently, extensive reports are yielded from cancer research. However, besides malignancy, EVs may also serve as crucial regulators in other devastating conditions, such as the acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). The generation, regulation and function of EVs in ARDS/ALI are largely unexplored. In this mini review, we will briefly review the current understanding of EVs and their known physiological/pathological functions in the pathogenesis of ARDS/ALI. Previously, only scattered reports have been published in this field. We believe that further investigations focusing on EVs and their compositions will shed light on novel insights in the research of ARDS/ALI.


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