alexa Extract of Garcinia kola Seed has Antitussive Effect and Attenuates Hypercholesterolemia in Rodents
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

Extract of Garcinia kola Seed has Antitussive Effect and Attenuates Hypercholesterolemia in Rodents

Ozolua RI1*, Saba AO1, Uwaya DO2, Abelega N1 and Oghuvwu SO3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria
2Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Benin City 300001, Nigeria
3Department of Internal Medicine, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria
Corresponding Author : Ozolua RI
Department of Pharmacology and Toxicology
Faculty of Pharmacy, University of Benin
Benin City 300001, Nigeria
Tel: +2348023528166
E-mail: [email protected]
Received: December 05, 2015; Accepted: January 28, 2016;Published: February 02, 2016
Citation: Ozolua RI, Saba AO, Uwaya DO, Abelega N, Oghuvwu SO (2016) Extract of Garcinia kola Seed has Antitussive Effect and Attenuates Hypercholesterolemia in Rodents. Med Aromat Plants 5:232. doi:10.4172/2167-0412.1000232
Copyright: © 2016 Ozolua RI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: The seeds of Garcinia kola Heckel (Guttiferrae) are widely eaten in West Africa for cultural and ethnomedicinal reasons including cough suppression and body fat reduction. We prepared a 70% ethanol extract and designed experiments to investigate the antitussive and anti-hypercholesterolemic effects. Methods: For the antitussive investigations, guinea pigs were exposed to 7.5% citric acid aerosol in a chamber and cough bouts were counted after acute doses of the extract. Mucus expectoration was evaluated in mice after administering the extract for seven days by measuring the concentration of phenol red dye released from mouse trachea. Hypercholesterolemia was induced and doses of the extract were administered for 14 days. Results: Single doses of 100, 200 and 400 mg/kg (p.o.) significantly (p<0.01) and dose-dependently suppressed cough bouts by 67, 78 and 92% respectively when compared cough bouts exhibited before treatment. The dose of 400 mg/kg was slightly but not significantly superior to the standard drug dihydrocodeine (84%) in cough suppression. The extract administered daily for 7 days also significantly (p<0.05) reduced concentration of phenol red released from mouse trachea in comparison with control. At 100, 200 and 400 mg/kg/day for 14 days, extract like 5 mg/kg simvastatin significantly (p<0.0001) attenuated the increase in plasma cholesterol level but only doses of 200 and 400 mg/kg/day significantly blunted increase in body weight compared to cholesterol treated rats. Conclusion: The extract possesses antitussive effect and attenuates hypercholesterolemia thereby lending credence to its ethnomedicinal uses.

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