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ISSN: 2157-7420

Journal of Health & Medical Informatics
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  • Research Article   
  • J Health Med Informat 2011, Vol 4(2)
  • DOI: 10.4172/2157-7420.S2-002

Extraction of Genetic Mutations Associated with Cancer from Public Literature

Martin Schenck1, Oliver Politz2 and Philip Groth2*
1Database Systems and Information Management, Technical University Berlin, , 10587 Berlin, Germany
2Therapeutic Research Group Oncology, Bayer Healthcare Pharmaceuticals, , 13353 Berlin, Germany
*Corresponding Author : Philip Groth, Therapeutic Research Group Oncology, Bayer Healthcare Pharmaceuticals, 13353 Berlin, Germany, Tel: +49 30 468196073, Fax: +49 30 468 18069, Email: [email protected]

Received Date: Nov 23, 2011 / Accepted Date: Dec 25, 2011 / Published Date: Jan 03, 2012

Abstract

Genomic mutations may result in severe diseases, e.g. cancer, a disease with a significant genetic component. The mutation state of cancer tissues is e.g. being determined experimentally in order to find the most likely response to a drug treatment. Results of such experiments are typically published in scientific literature. We have developed a workflow of several text-mining algorithms, in order to harvest this wealth of information relevant to developing novel therapeutic approaches in cancer. Our workflow has successfully scanned over 150,000 abstracts related to cancer and genetic mutations. New information on mutated genes in cancer could be extracted with a precision and recall of 86.8% and 30.3%, respectively. By applying the workflow, novel associations of mutations in specific cancer tissues could be extracted for 264 genes.

Keywords: Text mining; Mutations; Cancer

Citation: Schenck M, Politz O, Groth P (2012) Extraction of Genetic Mutations Associated with Cancer from Public Literature. J Health Med Informat S2:002. Doi: 10.4172/2157-7420.S2-002

Copyright: © 2012 Schenck M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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