alexa Extractive Spectrophotometric and Conductometric Methods for Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Extractive Spectrophotometric and Conductometric Methods for Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms

Safwan Ashour*, Mouhammed Khateeb and Ruba Mahrouseh

Analytical Biochemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Aleppo, Aleppo, Syria

*Corresponding Author:
Safwan Ashour
Analytical Biochemistry Laboratory
Department of Chemistry, Faculty of Sciences
University of Aleppo, Aleppo, Syria
Tel: 009-639-336-040-16
E-mail: [email protected]

Received date: May 09, 2013; Accepted date: May 23, 2013; Published date: May 27, 2013

Citation: Ashour S, Khateeb M, Mahrouseh R (2013) Extractive Spectrophotometric and Conductometric Methods for Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms. Pharm Anal Acta S2:003. doi: 10.4172/2153-2435.S2-003

Copyright: © 2013 Ashour S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Two simple and sensitive extractive spectrophotometric and conductometric methods have been developed for the determination of fexofenadine hydrochloride in bulk and in pharmaceutical preparations. The first method is based on the formation of colored chloroform extractable ion-association complexes (1:1) of fexofenadine with bromocresol purple (BCP) and bromophenol blue (BPB) dyes in aqueous acidic buffer pH 3.0. The extracted complex species were quantitatively measured at 411 and 415 nm for FEX-BCP and FEX-BPB, respectively (method I). The second method is based on the conductometric determination of 2.5-13.45 mg of fexofenadine by titration with sodium tetraphenylborate (TPB) in aqueous solution at 20°C (method II). All the reaction conditions for the proposed methods have been studied. Beer’s law was obeyed in the FEX concentration ranges 1.1-47.8 and 1.2-45.0 μg mL-1 with detection limit of 0.21 and 0.15 μg mL-1 for FEX-BCP and FEX-BPB, respectively. The proposed methods were applied successfully for the determination of the FEX in pharmaceutical formulations, the RSD% values were found to be 0.38, 0.24 and 0.74% for extractive spectrophotometric and conductometric methods, respectively. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.

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