alexa Extractive Spectrophotometric and Conductometric Methods for Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Extractive Spectrophotometric and Conductometric Methods for Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms

Safwan Ashour*, Mouhammed Khateeb and Ruba Mahrouseh

Analytical Biochemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Aleppo, Aleppo, Syria

*Corresponding Author:
Safwan Ashour
Analytical Biochemistry Laboratory
Department of Chemistry, Faculty of Sciences
University of Aleppo, Aleppo, Syria
Tel: 009-639-336-040-16
E-mail: [email protected]

Received date: May 09, 2013; Accepted date: May 23, 2013; Published date: May 27, 2013

Citation: Ashour S, Khateeb M, Mahrouseh R (2013) Extractive Spectrophotometric and Conductometric Methods for Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms. Pharm Anal Acta S2:003. doi: 10.4172/2153-2435.S2-003

Copyright: © 2013 Ashour S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Two simple and sensitive extractive spectrophotometric and conductometric methods have been developed for the determination of fexofenadine hydrochloride in bulk and in pharmaceutical preparations. The first method is based on the formation of colored chloroform extractable ion-association complexes (1:1) of fexofenadine with bromocresol purple (BCP) and bromophenol blue (BPB) dyes in aqueous acidic buffer pH 3.0. The extracted complex species were quantitatively measured at 411 and 415 nm for FEX-BCP and FEX-BPB, respectively (method I). The second method is based on the conductometric determination of 2.5-13.45 mg of fexofenadine by titration with sodium tetraphenylborate (TPB) in aqueous solution at 20°C (method II). All the reaction conditions for the proposed methods have been studied. Beer’s law was obeyed in the FEX concentration ranges 1.1-47.8 and 1.2-45.0 μg mL-1 with detection limit of 0.21 and 0.15 μg mL-1 for FEX-BCP and FEX-BPB, respectively. The proposed methods were applied successfully for the determination of the FEX in pharmaceutical formulations, the RSD% values were found to be 0.38, 0.24 and 0.74% for extractive spectrophotometric and conductometric methods, respectively. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version