Extraskeletal Intracranial Chondroma: Ultrastructural and Immunohistochemical FeaturesKhaldoon Aljerian*
Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- *Corresponding Author:
- Khaldoon Aljerian
MBBS, MHSc, FRCPC, Assistant Professor
Department of Pathology, College of Medicine
King Saud University, Riyadh,
Saudi Arabia (SA)
E-mail: [email protected]
Received date: Mar 25, 2015; Accepted date: Jun 04, 2015; Published date: Jun 06, 2015
Citation: Aljerian K (2015) Extraskeletal Intracranial Chondroma: Ultrastructural and Immunohistochemical Features J Carcinogene Mutagene 6:227. doi: 10.4172/2157-2518.1000227
Copyright: © 2015 Aljerian K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The discrete microvasculature environment of the perivascular plays a dominant role in regulating stem cell activity and its proliferation behavior. Mesenchymal stem cells (MSC) reside in perivascular compartment, hence have the potential to contribute to the pathogenesis of extra-skeletal intracranial chondroma (ESICC). In this case report, for the first time, the immunohistochemical (IHC) markers and transmission electron microscpoe (TEM) features of perivascular are presented in ESICC. Microscopic examination revealed a well-differentiated chondroma with foci of ossification and islands of vacuolated-cells encircling thin-walled capillaries. TEM showed transitional morphological features suggestive of transformation to chondrocytes, with vacuolated cells. A subpopulation of spindle vacuolated-cells displayed reaction for S-100, ferritin, trypsin-anti-chymotrypsin and Vimentin. As there was no evidence of transitional forms to arachnoid cells, it can be concluded that the origin of the recognized ICC is a perivascular multipotential mesenchymal cell, MSC.