alexa Ex-vivo Expansion of Muscle-Regenerative Cells for the Treatment of Muscle Disorders | OMICS International | Abstract
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
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Review Article

Ex-vivo Expansion of Muscle-Regenerative Cells for the Treatment of Muscle Disorders

Schaaf G1*#, Sage F2#, Stok M3, Brusse E4, Pijnappel WWM1, Reuser AJ1 and vd Ploeg AT1

1Department of Pediatrics and Department of Clinical Genetics, Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, Dr. Molewaterplein 50, 3015 GE, The Netherlands

2Department of Cell Biology, Stem Cell Institute, Erasmus MC University Medical Center, The Netherlands

3Department of Hematology, Erasmus MC University Medical Center, The Netherlands

4Department of Neurology, Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, The Netherlands

#Contributed equally

*Corresponding Author:
Schaaf G
Departments of Pediatrics and Dept of Clinical Genetics
Center for Lysosomal and Metabolic Diseases
Erasmus MC University Medical Center
Dr. Molewaterplein 50, 3015 GE, The Netherlands
E-mail: [email protected]

Received date: August 21, 2012; Accepted date: October 15, 2012; Published date: October 17, 2012

Citation: Schaaf G, Sage F, Stok M, Brusse E, Pijnappel WWM, et al. (2012) Ex-vivo Expansion of Muscle-Regenerative Cells for the Treatment of Muscle Disorders. J Stem Cell Res Ther S11:003. doi:10.4172/2157-7633.S11-003

Copyright: © 2012 Schaaf G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Skeletal muscle has an impressive regenerative potential. The cells that mediate muscle repair have unique properties that are not restricted solely to the formation of new muscle, but also contribute to the repair of damaged residual tissue. Recent studies have shown that freshly isolated muscle-regenerative cells maintain these properties, and contribute to muscle repair after transplantation to host muscle tissue. Muscle-regenerative cells are typically present in low numbers, and the yield of therapeutic cells from biopsies is low. Ex-vivo expansion of the candidate cells is therefore required. However, when cultured in vitro, the muscle-regenerative cells, and particularly muscle satellite cells, lose their regenerative capacities. This poses a major limitation on the introduction of cell-based therapies for muscle disorders. Here, we take the opportunity to review the promise of cell-based therapies specifically for the treatment of degenerative muscle diseases. We focus particularly on optimizing the conditions for expanding the cells in vitro in a way that maintains their regenerative properties.

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