alexa Fabrication and Evaluation of Fast Disintegrating Oral
ISSN: 2329-6631

Journal of Developing Drugs
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Research Article

Fabrication and Evaluation of Fast Disintegrating Oral Hybrid Films of Propranolol Hydrochloride by Using Pectin and Synthetic Polymers

Newton AMJ*, Rani SM and Sukhjinder K

Department of Pharmaceutics, Rayat-Bahra Institute of Pharmacy, Rayat-Bahra University, Punjab, India

*Corresponding Author:
Newton AMJ
Department of Pharmaceutics
Rayat-Bahra Institute of Pharmacy
Rayat-Bahra University
Punjab, India
Tel: +919878872510
E-mail: [email protected]

Received date: May 01, 2016; Accepted date: June 20, 2016; Published date: June 27, 2016

Citation: Newton AMJ, Rani SM, Sukhjinder K (2016) Fabrication and Evaluation of Fast Disintegrating Oral Hybrid Films of Propranolol Hydrochloride by Using Pectin and Synthetic Polymers. J Dev Drugs 5: 157. doi:10.4172/2329-6631.1000157

Copyright: © 2016 Newton AMJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The main aim of this investigation is to develop fast disintegrating oral films of Propranolol hydrochloride by using Pectin and synthetic polymers. The Propranolol HCl oro-dispersible films were formulated by using HPMC E15LV, HPMC regular, pectin, Carbopol, and PVA, as film forming polymers. The selected polymers were natural and synthetic water soluble polymers. Generally solvent casting method was used in the manufacture of the mouth dissolving films. The formula which incorporates pectin HPMC E15 LV 4:2 and pectin: Carbopol 3:2 ratios and also other varying ratio were used in the formulation of Oro-dispersible films. The quantity and type of plasticizer affected the formulation of films; Propranolol HCl has bitter taste so taste masking agents were used. Citric acid was used as a salivary stimulating agent. The prepared films were subjected to the analysis of various evaluation tests such as weight variation, tensile strength, thickness, surface pH, and drug content. The significant parameters such as disintegration and dissolution profiles also studied in detail since the product was prepared for fast dissolving in the oral cavity.


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