alexa Fabrication Factory for Tubular Vascular Tissue Mimics based on Automated Rolling Manipulation and Thermo-Responsive Polymers
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Research Article

Fabrication Factory for Tubular Vascular Tissue Mimics based on Automated Rolling Manipulation and Thermo-Responsive Polymers

Takehisa Matsuda1,2*, Toshihiko Shirota2,3 and Daigo Kawahara1,2

1Genome Biotechnology Laboratory, Kanazawa Institute of Technology 3-1, Yatsukaho, Hakusan, Ishikawa, Japan

2Department of Biomedical Engineering, Kyushu University Graduate School of Medicine16, Maidashi, Fukuoka, Fukuoka, Japan

3Department of Cardiovascular Surgery, Kyushu University Graduate School of Medicine 16, Maidashi, Fukuoka, Fukuoka, Japan

Corresponding Author:
Takehisa Matsuda
Genome Biotechnology Laboratory, Kanazawa Institute of Technology 3-1
Yatsukaho, Hakusan, Ishikawa, Japan
Tel: 81-76-274-7934
E-mail: [email protected]

Received date: December 02, 2013; Accepted date: January 09, 2014; Published date: January 11, 2014

Citation: Matsuda T, Shirota T, Kawahara D (2014) Fabrication Factory for Tubular Vascular Tissue Mimics based on Automated Rolling Manipulation and Thermo-Responsive Polymers. J Tissue Sci Eng 5:134. doi:10.4172/2157-7552.1000134

Copyright: © 2014 Matsuda T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



This study presents a novel methodology for fabrication of tubular vascular tissue mimics by an automated factory using thermoresponsive polymers which have temperature-induced reversible phase transition characteristics; Poly(N-Isopropylacrylamide)-Grafted Gelatin (PNIPAM-gelatin), PNIPAM and gelatin. The custom-designed factory consists of a moving tray, a roller unit driven by rack-and-pinion mechanics, and a local temperature-control unit. PNIPAM-gelatin serves as the matrix, providing temperature-dependent adhesion and detachment of cell sheets. We describe two prototypes of vascular tissue mimics: a tubular medial tissue mimic composed of randomly oriented Smooth Muscle Cells (SMCs), and a hierarchically structured vascular tissue mimic (intimal/medical tissue mimics) composed of longitudinally oriented Endothelial Cells (ECs) on the luminal surface and circumferentially oriented multilayered SMCs in the outer layer. We observed these prototypes under electron microscopes and a Confocal Laser-Scanning Microscope (CLSM). An advanced model of our prototype factory would have the potential to produce high-quality on-demand vascular grafts without incorporating any foreign materials.


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