Fabrication of Nanoparticles of Silymarin, Hesperetin and Glibenclamide by Evaporative Precipitation of Nanosuspension for Fast DissolutionKakran M1,2, Sahoo GN1, Lin Li1*
- *Corresponding Author:
- Lin L
School of Mechanical and Aerospace Engineering
Nanyang Technological University
50 Nanyang Avenue, Singapore 639798
Tel:+65 6790 6285
E-mail: [email protected]
Received date: November 19, 2014; Accepted date: December 10, 2014; Published date: January 15, 2015
Citation: Kakran M, Sahoo GN, Li L (2015) Fabrication of Nanoparticles of Silymarin, Hesperetin and Glibenclamide by Evaporative Precipitation of Nanosuspension for Fast Dissolution. Pharm Anal Acta 6:326. doi: 10.4172/2153-2435.1000326
Copyright: © 2015 Kakran M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Evaporative precipitation of nanosuspension (EPN) was used to prepare nanoparticles of poorly water soluble drugs, namely silymarin (SLM), hesperetin (HSP) and glibenclamide (GLB), with the aim of improving their rate of dissolution. The original drugs and EPN prepared drug nanoparticles were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and dissolution tester. The particle sizes were found to be influenced by the drug concentration and the solvent to antisolvent ratio. The smallest average particle sizes obtained were 350 nm for SLM, 450 nm for HSP and 120 nm for GLB. The DSC study suggested that the crystallinity of EPN prepared drug nanoparticles was lower than the original drug. The dissolution rate of EPN prepared drug nanoparticles markedly increased as compared to original drug. The dissolution rate was increased by up to 95% for SLM nanoparticles, up to 90% for HSP and up to almost 100% for the GLB nanoparticles fabricated. From this study, it can be concluded that the EPN is an effective method to fabricate drug nanoparticles with enhanced dissolution rate.