alexa Factors Affecting Long-Term Safety of Trastuzumab in Patients with Early HER2-Positive Breast Cancer | OMICS International | Abstract
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Factors Affecting Long-Term Safety of Trastuzumab in Patients with Early HER2-Positive Breast Cancer

Boekhout AH1*, Werkhoven ED2, Liebergen R3, Korse CM4, Burylo A5, Trip AK6, Beijnen JH7,8 and Schellens JH1,8
1Division of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands
2Biometrics Department, Netherlands Cancer Institute, Amsterdam, The Netherlands
3Department of Cardiology, Slotervaart Hospital, Amsterdam, The Netherlands
4Department of Clinical chemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands
5Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands
6Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
7Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
8Department of Pharmaceutical Sciences, Science Faculty Utrecht University, Utrecht, The Netherlands
*Corresponding Author : Boekhout AH
Division of Clinical Pharmacology
Netherlands Cancer Institute. Plesmanlaan 121
1066 CX, Amsterdam, The Netherlands
Tel: 312-051-224-46
Fax: 312-051-225-72
E-mail: [email protected]
Received July 25, 2014; Accepted September 24, 2014; Published September 26, 2014
Citation: Boekhout AH, Werkhoven ED, Liebergen R, Korse CM, Burylo A, et al. (2014) Factors Affecting Long-Term Safety of Trastuzumab in Patients with Early HER2-Positive Breast Cancer. Adv Pharmacoepidemiol Drug Saf 3:160. doi:10.4172/2167-1052.1000160
Copyright: © 2014 Boekhout AH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Trastuzumab treatment is associated with cardiac dysfunction. We evaluated the incidence of cardiotoxicity during and long-term after trastuzumab treatment in an unselected early breast cancer population.
Methods: This study included a retrospective part, the chemotherapy- and trastuzumab treatment period and a prospective part, the period of data collection long-term after trastuzumab treatment. Cardiac evaluation included left ventricular ejection fraction (LVEF) changes and an evaluation of symptomatic cardiotoxicity. Cardiac events were defined as a decrease of 10 percentage points in LVEF compared with baseline and to an absolute LVEF of below 50%. Secondary outcomes included the evaluation of cardiac markers (B-type natriuretic peptide and troponins) and single nucleotide polymorphisms (SNPs) in the HER2 gene as parameters to detect or predict trastuzumab-related cardiotoxicity.
Results: Overall, 105 patients were evaluable for the primary endpoint. The 3-year cumulative incidence of cardiac events was 12% (95 CI, 4%-19%). All 8 patients with a cardiac event were pre-treated with anthracyclines and cyclophosphamide and 7 of them recovered partially or completely. Four patients experienced symptomatic cardiotoxicity, of who 2 recovered completely and the other 2 recovered partially. No statistically significant association was observed between cardiac events and cardiac markers or SNPs.
Conclusion: Trastuzumab treatment in combination with anthracy

cline-based chemotherapy is associated with significant and only partly reversible cardiac dysfunction. Baseline LVEF value is a prominent predictor for long-term LVEF especially, in patients who are not treated with anthracycline-based chemotherapy. These findings can be used to establish optimal monitoring strategies in trastuzumab treatment.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7