Factors Influencing the Outcome of Hematopoietic Stem Cell Transplantation in Pediatric Acute Myeloid Leukemia: Single Institution Results from Saudi ArabiaAl-Sweedan S1,2*, Siddiqui K1, Jafri R1, Al-Ahmari A1, Ayas M1 and Al-Seraihy A1
- *Corresponding Author:
- Al-Sweedan S
Department of Pediatric Hematology and Oncology
King Faisal Specialist Hospital and Research Center
P.O. Box 3354, Riyadh 11211, Saudi Arabia
Tel: (+966) 11 20 55289
Fax: (+966) 11 20 55276
E-mail: [email protected]
Received Date: March 21, 2017; Accepted Date: April 10, 2017; Published Date: April 17, 2017
Citation: Al-Sweedan S, Siddiqui K, Jafri R, Al-Ahmari A, Ayas M, et al. (2017) Factors Influencing the Outcome of Hematopoietic Stem Cell Transplantation in Pediatric Acute Myeloid Leukemia: Single Institution Results from Saudi Arabia. J Blood Lymph 7: 163. doi: 10.4172/2165-7831.1000163
Copyright: © 2017 Al-Sweedan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Medical records of 73 patients with AML who underwent HCT, 2005-2011. The OS was 51.8% and the EFS were 48%. Median follow-up time for the cohort was 50.667 ± 2.4 months (95%CI: 45.9-55.4). 39 patients were alive with a median follow-up time of 50.1 months (Min: 1.8, Max: 111.8). Sixteen patients survived for more than 5 years (Min: 65.2, Max: 111.8 months). The cumulative incidence of acute GVHD was 6.8 ± 2.9 and of chronic GVHD was 9.9 ± 3.6. Median time to ANC and platelet recovery was 16 days (range 9-37) and 29 days (range 15-180) respectively. Three patients acquired CMV infection after transplant. There was a significant impact of patient’s age at diagnosis on the overall survival (Infantile: 100%, others: 45.6% ± 6.4%, P=0.016) and event free survival (Infantile: 100%, others: 40.6% ± 7.1%, P=0.013). Percentage of blasts at transplant, patients or donors gender, donor source and HLA disparity did not significantly affect OS or EFS.