alexa Facts, Challenges, Difficulties and Hopes in Single-Cell Biology: Physiopathological Studies
ISSN: 2168-9431

Single Cell Biology
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Commentary

Facts, Challenges, Difficulties and Hopes in Single-Cell Biology: Physiopathological Studies

Francesco Salvatore1,2*, Federica Cariati1 and Rossella Tomaiuolo1,3
1CEINGE-Biotecnologie Avanzate, via G. Salvatore 486, 80145 Naples, Italy
2IRCCS-Fondazione SDN, 80143 Naples, Italy
3Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy
Corresponding Author : Francesco Salvatore
M.D., Ph.D., CEINGEBiotecnologieAvanzate
via Gaetano Salvatore 486
80145 Naples, Italy
Tel: +39 081 7463133
Fax: +39 081 7463650
E-mail: [email protected]
Received August 10, 2015; Accepted September 10, 2015; Published September 12, 2015
Citation: Salvatore F, Cariati F, Tomaiuolo R (2015) Facts, Challenges, Difficulties and Hopes in Single-Cell Biology: Physiopathological Studies. Single Cell Biol 4:121. doi:10.4172/2168-9431.1000121
Copyright: © 2015 Salvatore F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Single-cell approaches are being increasingly used to unravel the many diverse mechanisms underlying biological processes that characterize each cell irrespective of the influx of other cells even within the same tissue. Consequently, the interference of metabolites and nervous stimuli emanating from the circulatory or nervous system in a higher organism like man is avoided. However, while the single-cell approach yields a wealth of data about single-cell metabolism and internal regulatory mechanisms, information about interactions and interrelations among similar or dissimilar cells may remain obscure. Starting from these considerations, here we summarize, without attempting to be exhaustive, some areas in which we think single-cell biological studies could be effective in translational medicine and in other areas of applied sciences. In this short review we describe the facts, challenges and perspectives related to these issues.

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