alexa False Sero-Negative Results for Helicobacter Pylori Inf
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

False Sero-Negative Results for Helicobacter Pylori Infection Indicate Increased Risk of Severe Atrophic Gastritis in Japanese Patients

Hitomi Ichikawa1, Mitsushige Sugimoto1, Mihoko Yamade1, Takahiro Uotani1, Shu Sahara1, Takuma Kagami1, Yasushi Hamaya2, Moriya Iwaizumi1, Satoshi Osawa3, Ken Sugimoto1, Hiroaki Miyajima1 and Takahisa Furuta4*
1First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu,Japan
2Department of Clinical Oncology, Hamamatsu University School of Medicine, Hamamatsu, Japan
3Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu,Japan
4Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
Corresponding Author : Takahisa Furuta, MD, PhD
Center for Clinical Research
Hamamatsu University School of Medicine
1-20-1, Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan
Tel: 81-53-435-2850
Fax: 81-53-435-2851
E-mail: [email protected]
Received August 13, 2014; Accepted September 18, 2014; Published September 23, 2014
Citation: Ichikawa H, Sugimoto M, Yamade M, Uotani T, Sahara S, et al. (2014) False Sero-Negative Results for Helicobacter Pylori Infection Indicate Increased Risk of Severe Atrophic Gastritis in Japanese Patients. J Carcinog Mutagen 5:192. doi: 10.4172/2157-2518.1000192
Copyright: © 2014 Ichikawa H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background/objective: H. pylori infection is commonly diagnosed using an anti-H. pylori IgG antibody test. However, a proportion of results are falsely sero-negative. We investigated characteristics of patients falsely seronegative for H. pylori in relation to gastric atrophy. Methods: H. pylori infection (Hp+ or Hp-) was determined based on culture test, rapid urease test (RUT), and polymerase chain reaction (PCR) test in 280 outpatients. Anti-H. pylori antibody titers ≥ 10 U/ml were diagnosed as sero-positive for H. pylori (IgG+), while those <10 U/ml were sero-negative (IgG-). Serum pepsinogen (PG) I/PG II ratios were calculated as a serological marker of gastric atrophy. Endoscopic gastric mucosal atrophy was also assessed according to the Kimura-Takemoto classification system. Results: The mean PG I/PG II ratio in each group was as follows: Hp-/IgG- (4.99 ± 1.04, n=10), Hp+/IgG+ (2.59 ± 1.51, n=240), Hp-/IgG+ (5.65 ± 2.72, n=4) and Hp+/IgG- (3.02 ± 2.61, n=26). The mean serum PG I/PG II ratio in the Hp+/IgG- group was lower than those of Hp-/IgG- and Hp-/IgG+ groups (P=0.028 and 0.072). Incidence of severe gastric mucosal atrophy in the Hp+/IgG- group was highest of the four groups. Conclusions: Individuals falsely sero-negative for H. pylori infection is at increased risk of severe atrophic gastritis, which is well known as precancerous lesion.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords