Familial Aggregation of Hypercholesterolemia in Pakistani PopulationFauzia Imtiaz1 and Ahsan A. Vahidy2*
- *Corresponding Author:
- Dr. Fauzia Imtiaz
B-237, Block-N, North Nazimabad, Karachi-Pakistan
E-mail: [email protected]
Received date: December 20, 2011; Accepted date: May 04, 2012; Published date: May 08, 2012
Citation: Imtiaz F, Vahidy AA (2012) Familial Aggregation of Hypercholesterolemia in Pakistani Population. Hereditary Genet 1:109 doi: 10.4172/2161-1041.1000109
Copyright: © 2012 Imtiaz F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: To estimate the familial aggregation of hypercholesterolemia among Pakistani population live in the
metropolitan area Karachi.
Methods: The present study was conducted during the period of 2007 to 2009 on the sample population of Karachi
Pakistan. In the present study, 478 family members (age ranges from 20 to 65 years), from ten-hypercholesterolemic
probands (Cholesterol level > 300 mg/dl) were studied and their serum cholesterol level was estimated to see the
familial aggregation of the disease. The clinical examination was also performed to see the presence of tandinous
xanthmata, xanthelesma, arcus cornea and polyarthritis.
Results: Parent-offspring correlation and heritability is calculated by using the statistical package for social sciences
(SPSS) version 16.0. A significant positive correlation of cholesterol was found among parents and their offspring
(r=0.589, p=0.01, n=86). Relationship between father–son, father–daughter, mother–son and mother–daughter were
highly significant with b= 0.794, 0.41, 0.766 and 0.56 respectively. This study confirmed the familial aggregation of
serum cholesterol level in Pakistani population and the heritability was calculated as 0.438 (43.8%).
Conclusion: The heritability of hypercholesterolemia and their clinical presentation was studied in the families
which confirmed its familial aggregation in Pakistani population.