alexa Familial Aggregation of Hypercholesterolemia in Pakistani Population
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Familial Aggregation of Hypercholesterolemia in Pakistani Population

Fauzia Imtiaz1 and Ahsan A. Vahidy2*

1 Department of Biochemistry, Dow International Medical College, Dow University of Health Sciences, Pakistan

2 Department of Genetics, University of Karachi, Pakistan

*Corresponding Author:
Dr. Fauzia Imtiaz
B-237, Block-N, North Nazimabad, Karachi-Pakistan
Cell: 0300-2116211
Tel: 9221-35478727
E-mail: [email protected]

Received date: December 20, 2011; Accepted date: May 04, 2012; Published date: May 08, 2012

Citation: Imtiaz F, Vahidy AA (2012) Familial Aggregation of Hypercholesterolemia in Pakistani Population. Hereditary Genet 1:109 doi: 10.4172/2161-1041.1000109

Copyright: © 2012 Imtiaz F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: To estimate the familial aggregation of hypercholesterolemia among Pakistani population live in the
metropolitan area Karachi.
Methods: The present study was conducted during the period of 2007 to 2009 on the sample population of Karachi
Pakistan. In the present study, 478 family members (age ranges from 20 to 65 years), from ten-hypercholesterolemic
probands (Cholesterol level > 300 mg/dl) were studied and their serum cholesterol level was estimated to see the
familial aggregation of the disease. The clinical examination was also performed to see the presence of tandinous
xanthmata, xanthelesma, arcus cornea and polyarthritis.
Results: Parent-offspring correlation and heritability is calculated by using the statistical package for social sciences
(SPSS) version 16.0. A significant positive correlation of cholesterol was found among parents and their offspring
(r=0.589, p=0.01, n=86). Relationship between father–son, father–daughter, mother–son and mother–daughter were
highly significant with b= 0.794, 0.41, 0.766 and 0.56 respectively. This study confirmed the familial aggregation of
serum cholesterol level in Pakistani population and the heritability was calculated as 0.438 (43.8%).
Conclusion: The heritability of hypercholesterolemia and their clinical presentation was studied in the families
which confirmed its familial aggregation in Pakistani population.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version