Familial Non Medullary Thyroid Cancer: Clinic Cases and Review of literature
|R. Ciuni*, C. Spataro, S. Nicosia, A. Biondi, F. Basile and S. Ciuni|
|Department of General Surgery, Az-Osp Policlinico –Vittorio Emanuele, University Of Catania, Italy|
|Corresponding Author :||Ciuni Roberto
Department of General Surgery
Az-Osp Policlinico –Vittorio Emanuele
University Of Catania, Italy
E-mail: [email protected]
|Received April 13, 2012; Accepted May 23, 2012; Published June 08, 2012|
|Citation: Ciuni R, Spataro C, Nicosia S, Biondi A, Basile F, et al. (2012) Familial Non Medullary Thyroid Cancer: Clinic Cases and Review of literature. Thyroid Disorders Ther 1:111. doi:10.4172/2167-7948.1000111|
|Copyright: © 2012 Ciuni R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Introduction: Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazole, methimazole and Benzylthiouracil. Benzylthiouracil –induced Vasculitis are often severe forms with renal or pulmonary involvement, which can be life-threatening if left untreated. We describe the clinical course and medical management of 2 cases of severe vasculitis with alveolar hemorrhage and renal involvement occurred in 2 patients with Graves’ disease treated by Benzylthiouracil.
Cases report: A 36 and 33-year-old women with Graves’ disease developed alveolar hemorrhage and acute renal failure after respectively 36 and 144 months of Benzylthiouracil therapy. Kidney biopsy showed pauci-immune crescentic glomerulonephritis in the 2 cases. Anti Neutrophil Cytoplasmic Antibody (ANCA) was positive (P- ANCA in the first patient and c-ANCA in the second patient). The condition of the first patient improved when Benzylthiouracil was withdrawn associated with corticosteroids and immunosuppressive treatment after a follow up of 6 months. However, the second patient died by severe infection after the same treatment.
Conclusion: Benzylthiouracil vasculitis is a serious complication but its prognosis is good if diagnosis and treatment are early. However mortality is related to risk of infection.