Journal of Alzheimers Disease & Parkinsonism
Open Access

Mini Review

Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research

Xiang Gao^1†, Yuhong Gan^2†, Kefeng Wu², Wende Li^2,3* and Ren Huang³

¹Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China

²Guangdong Key Laboratory for Research and Development of Natural Drug, Guangdong Medical College, Zhanjiang, Guangdong, China

³Guangdong Key Laboratory of Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China

⁴† Equal contributors

*Corresponding Author:

Wende Li
Guangdong Key Laboratory for Research and Development of Natural Drug
Guangdong Medical College, Zhanjiang, Guangdong, China
Tel: 0759-2230067
E-mail: lwd@gdlami.com

Received date September 18, 2016; Accepted date October 12, 2016; Published date October 19, 2016

Citation: Gao X, Gan Y, Wu K, Li W, Huang R (2016) Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research. J Alzheimers Dis Parkinsonism 6:272. doi:10.4172/2161-0460.1000272

Copyright: © 2016 Gao X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been wildly considered for positive effect of Alzheimer’s disease (AD). However, the intake of n-3 PUFAs is not encouraging to draw firm conclusion through preclinical and clinical research. The contribution of debate is derived from interference of dietary n-3 PUFAs, because of controlling the components and ratio of dietary PUFAs difficultly. In this context, transgenic fat-1 mouse that is capable of converting n-6 to n-3 fatty acids by feeding high n-6 PUFAs diet, leading to balance high n-3/n-6 PUFAs ratio, with increasing endogenous n-3 PUFAs and decreasing n-6 PUFAs in their organs and tissues. Thus, fat-1 mice is an ideal model to study the efficacy and mechanism of n-3 PUFAs in AD research, without the interference of the inevitable factors from dietary n-3 PUFAs. The fat-1 transgenic mice have become a useful tool for studying the potential benefit of endogenous n-3 PUFAs in behavior and neuromechanism of AD.

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