alexa Fatal Invasive Aspergillosis in Acute Lymphoblastic Leukemia Patient
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Fatal Invasive Aspergillosis in Acute Lymphoblastic Leukemia Patient

Parahym AMRDC1*, Neto PJR1, Silva CMD1, Gonçalves SS2, Motta CMDS1, Filho GADTMH3, Correia TTDS1 and Neves RP1
1Federal University of Pernambuco, Recife, PE, Brazil
2Special Mycology Laboratory, São Paulo, SP, Brazil
3Hematology and Hemotherapy Foundation of Pernambuco-HEMOPE, Recife, PE, Brazil
Corresponding Author : Ana Maria Rabelo de Carvalho Parahym
Avenida Nelson Chaves, s/n
Cidade Universitária
Recife-PE, 50670-420, Brazil
Tel: (+5581) 21268570
Fax: (+5581) 21268482
E-mail: [email protected]
Received May 08, 2014; Accepted May 20, 2014; Published May 22, 2014
Citation: Parahym AMRDC, Neto PJR, Silva CMD, Gonçalves SS, Motta CMDS, et al. (2014) Fatal Invasive Aspergillosis in Acute Lymphoblastic Leukemia Patient. J Clin Case Rep 4:368. doi:10.4172/2165-7920.1000368
Copyright: © 2014 Parahym AMRDC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Invasive aspergillosis (IA) is one of the most common fungal infections in immunocompromised patients. Is an air-borne disease and the majority of patients develop pneumonia or sinusitis. However central nervous system (CNS) aspergillosis may also occur. Infections by Aspergillus fumigatus are most prevalent although in recent years, non-fumigatus Aspergillus species such as A. flavus has become common as causal agents this mycosis. The major risk factors associated include neutropenia, hematological malignancy,andtransplantation of hematopoietic stem cells and solid organs. Therefore, here we report a fatal case of pulmonary aspergillosis and CNS due Aspergillus flavus in neutropenic patient with acute lymphoblastic leukemia. The diagnosis of pulmonary infection was based in the isolation of A. flavus in tracheal secretions associated with the pulmonary infiltration detected in the Chest X-ray. Because of the thrombocytopenia the CNS aspergillosis was diagnosed only by brain magnetic resonance imaging. This case underscores the Importance of IA as a serious disease and late diagnosis leading to a poor prognosis with fatal course due to worsening clinical.

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