alexa Fatal Nitrofurantoin-Induced Pulmonary Toxicity: A Potentially Preventable Medical Error
ISSN: 2327-4972

Family Medicine & Medical Science Research
Open Access

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Case Report

Fatal Nitrofurantoin-Induced Pulmonary Toxicity: A Potentially Preventable Medical Error

Chakra P Chaulagain*
Department of Medicine, Division of Hematology and Oncology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Corresponding Author : Chakra P Chaulagain
800 Washington St, Box 245
Boston, MA 02111, USA
E-mail: [email protected]
Received December 30, 2013; Accepted March 21, 2014; Published March 23, 2014
Citation: Chaulagain CP (2014) Fatal Nitrofurantoin-Induced Pulmonary Toxicity: A Potentially Preventable Medical Error. Fam Med Med Sci Res 3:118. doi:10.4172/2327-4972.1000118
Copyright: © 2014 Chaulagain CP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Nitrofurantoin is a commonly prescribed urinary antiseptic both for acute treatment and prophylaxis against recurrent urinary tract infections. It is known for its safety, efficacy, tolerability and cost-effectiveness. Rarely, nitrofurantoin can cause acute and chronic lung and liver diseases. Acute pulmonary toxicity due to nitrofurantoin is more common than its chronic form and is probably a hypersensitivity reaction to the drug. In contrast, the chronic pulmonary toxicity appears to be due to cumulative drug exposure leading to chronic inflammation and fibrosis and is therefore an irreversible process. What predisposes to the rare and severe form of acute pulmonary toxicity is unknown. In this case, it appears that renal impairment may have played a role as a predisposing factor.

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