alexa Feasibility of Intermittent Fish Oil Infusions in Outpatients with Graft- Versus-Host Disease of the Digestive Tract
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

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Research Article

Feasibility of Intermittent Fish Oil Infusions in Outpatients with Graft- Versus-Host Disease of the Digestive Tract

Barbara van der Meij1*, Visser OJ2, Langius JAE1, Hacquebard M3 and van Leeuwen PAM4

1Department of Nutrition and Dietetics, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands

2Department of Haematology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands

3Laboratories of Experimental Surgery, Brussels Free University; C/O Nutrisub, Avenue J. Wybran 40, 1070 Brussels, Belgium

4Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands

*Corresponding Author:
Barbara van der Meij
Department of Nutrition and Dietetics
VU University Medical Center De Boelelaan 1117
1007 MB, Amsterdam, The Netherlands
Tel: +3162-674-2954
Fax: +3120-444-4143
E-mail: [email protected]

Received Date: March 02, 2013; Accepted Date: March 21, 2013; Published Date: March 23, 2013

Citation: Meij Bvd, Visser OJ, Langius JAE, Hacquebard M, van Leeuwen PAM (2013) Feasibility of Intermittent Fish Oil Infusions in Outpatients with Graft-Versus- Host Disease of the Digestive Tract. J Nutr Food Sci 3:201. doi: 10.4172/2155-9600.1000201

Copyright: © 2013 Meij Bvd, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

N-3 polyunsaturated fatty acids from fish oil may have immune-modulating effects in Graft-versus-Host Disease of the digestive tract (GVHD-DT). The objective of this pilot study was to investigate feasibility, safety and effects on fatty acid composition of plasma lipids and white blood cells (WBC), following intermittent fish oil infusion in outpatients with chronic GVHD-DT. Four outpatients received intermittent infusion of a 10% fish oil emulsion (Omegaven) during 4 hours, at day 1 (1.5 mL/kg), 3 (2.25 mL/kg) and 5, 8, 10 and 12 (3 mL/kg). At baseline and consecutive visits, fatty acid composition of plasma triglycerides (TG), plasma phospholipids (PL) and WBC, serum TG concentrations, routine laboratory tests, as well as adverse events were monitored. During the fish oil infusions, serum TG increased, but decreased 2 h after termination of infusion. In 3 patients, the dose of Omegaven® needed to be reduced. EPA was incorporated into plasma PL, plasma TG and WBC as of 2 days after the first infusion; peak levels of EPA were reached at the final infusion, or 2 days after. In conclusion, intermittent fish oil infusions result in incorporation of EPA in plasma and WBC, but can be complicated by a reversible increase in serum triglycerides.

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